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Contents: Introduction; The origin and antiquity of syphilis: paleopathological diagnosis and interpretation, Brenda J. Baker and George J. Armelagos; Disease and the depopulation of Hispaniola, 1492-1518, Noble David Cook; New World depopulation and the case of disease, Donald Joralemon; Conquistador y pestilencia: the first New World pandemic and the fall of the great Indian empires, Alfred W. Crosby; An outline of Andean epidemic history to 1720, Henry F. Dobyns; Epidemiology and the slave trade, Philip D. Curtin; The influence of disease on race, logistics, and colonization in the Antilles, Francisco Guerra; Fear of hot climates in the Anglo-American colonial experience, Karen Ordahl Kupperman; Of agues and fevers: malaria in the early Chesapeake, Darrett B. Rutman and Anita H. Rutman; Smallpox and the Indians in the American colonies, John Duffy; The significance of disease in the extinction of the New England Indians, Sherburne F. Cook; Smallpox in aboriginal Australia, 1829-1831, Judy Campbell; Disease and infertility: a new look at the demographic collapse of native populations in the wake of western contact, David E. Stannard; Creative disruptions in American agriculture, 1620-1820, E. L. Jones; Europe’s initial population explosion, William L. Langer; Index.