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Introduction, Peter M. Monti, Suzanne M. Colby, and Tracy A. O'LearyI. Background and Context: Theory, Developmental, and Measurement Considerations1. Developmental Matters: Taking the Long View on Substance Abuse Etiology and Intervention during Adolescence, John Schulenberg, Jennifer L. Maggs, Kenneth J. Steinman, and Robert A. Zucker2. The Harm Reduction Approach to the Secondary Prevention of Alcohol Problems in Adolescents and Young Adults: Considerations across a Developmental Spectrum, Elizabeth T. Miller, Aaron P. Turner, and G. Alan Marlatt3. Assessing Adolescent Substance Use Problems and Other Areas of Functioning: State of the Art, Ken C. Winters4. Personality and Learning Factors Combine to Create Risk for Adolescent Problem Drinking: A Model and Suggestions for Intervention, Gregory T. Smith and Kristen G. AndersonII. Empirical Illustrations Linked to Part I/Clinical Applications and Brief Interventions5. Motivational Enhancement for Alcohol-Involved Adolescents, Peter M. Monti, Nancy P. Barnett, Tracy A. O'Leary, and Suzanne M. Colby6. Alcohol Skills Training for College Students, Elizabeth T. Miller, Jason R. Kilmer, Eleanor L. Kim, Kenneth R. Weingardt, and G. Alan Marlatt7. Integrative Behavioral and Family Therapy for Adolescent Substance Abuse, Holly Barrett Waldron, Janet L. Brody, and Natasha Slesnick8. Motivational Interviewing and the Prevention of HIV among Adolescents, Larry K. Brown and Kevin J. Lourie9. Toward Brief Interventions for Adolescents with Substance Abuse and Comorbid Psychiatric Problems, Mark G. Myers, Sandra A. Brown, Susan Tate, Ana Abrantes, and Kristin Tomlinson10. New Frontiers: Using the Internet to Engage Teens in Substance Abuse Prevention and Treatment, Harvey Skinner, Oonagh Maley, Louise Smith, Shawn Chirrey, and Meg MorrisonIII. Future Directions11. Transdisciplinary Research to Improve Brief Interventions for Addictive Behaviors, David B. Abrams and Richard R. Clayton