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FOREWORD 1. INTRODUCTION2. PBPK, QSAR and TOXICITY PATHWAYS: CHEMICAL SCREENING  AND PRIORITZATION TOOLS3. COMPUTATIONAL RISK ASSESSMENT OF UNTESTED HAZARDOUS CHEMICAL AGENTS RELEASTED IN THE WATER ENVIRONMENT4. RISK ASSESSMENT OF CHEMICAL MIXTURES5. MODELING SENSITIVE SUB-POPULATIONS FOR RISK ASSESSMENT6. COMPUTATIONAL METHODS FOR TOXICOGENOMIC ANALYSES FOR RISK ASSESSMENT7. INTEGRATED SYSTEMS BIOLOGY APPROACHES TO PREDICTING DRUG-INDUCED LIVER TOXICITY8. COMPUTATIONAL TRANSLATION AND INTEGRATION OF TEST DATA TO MEET RISK ASSESSEMENT GOALS9. COMPUTATIONAL TRANSLATION OF DATA FROM NON-MAMMALIAN SPECIES TO MEET REACH INFORMATIONAL STRATEGIES10. DEVLOPMENT OF IN SILICO TISSUE MODELS FOR RISK ASSESSMENT11. EXAMPLES OF SIMULATIONS WITH A NEWLY DEVELOPED GENERIC  PBTK -MODEL FOR INCORPORATING HUMAN BIOMONITORING  DATA TO MEET REACH GUIDELINES12. USE OF PUBLIC DATA SETS for RISK ASSESSMENT  13. COMPUTATIONAL TOXICOLOGY AND APPLICATIONS FOR RISK ASSESSMENTS OF PHARMACEUTICALS14. DECISION FOREST: A NOVEL PATTERN RECOGNITION METHOD FOR IN SILICO RISK ASSESSMENT15. TRANSLATION OF COMPUTATIONAL MODEL RESULTS16. FUTURE RESEARCH NEEDS