内容

目次

1: Drugs and drug targets - an overview PART A Drug targets- structure and function 2: Protein structure and function 3: Enzymes: structure and function 4: Receptors: structure and function 5: Receptors and signal transduction 6: Nucleic acids: structure and function PART B Pharmacodynamics and pharmacokinetics 7: Enzymes as drug targets 8: Receptors as drug targets 9: Nucleic acids as drug targets 10: Miscellaneous drug targets 11: Pharmacokinetics and related topics Case study 1: Statins PART C Drug discovery, design, and development 12: Drug discovery: finding a lead 13: Drug design: optimizing target interactions 14: Drug design: optimizing access to the target 15: Getting the drug to market Case study 2: The design of ACE inhibitors Case study 3: Artemisinin and related antimalarial drugs Case study 4 : The design of oxamniquine PART D Tools of the trade 16: Combinatorial synthesis 17: Computers in medicinal chemistry 18: Quantitative structure-activity relationships (QSAR) Case study 5: De novo design of a thymidylate synthase inhibitor PART E Selected topics in medicinal chemistry 19: Antibacterial agents 20: Antiviral agents 21: Anticancer agents 22: Cholinergics, anticholinergics, and anticholinesterases 23: Drugs acting on the adrenergic nervous system 24: Opioid analgesics 25: Antiulcer agents Case study 6: Steroidal anti-inflammatory agents Case Study 7: Design of a novel antidepressant Appendices