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目次

Preface Definition of Symbols Non-Proprietary and Brand Names ofDrugs in Text and Illustrations I. Basic Considerations 1. TherapeuticRelevance 2. Fundamental Concepts and Terminology II. Exposure andResponse after a Single Dose 3. Kinetics Following an Intravenous BolusDose 4. Membranes and Distribution 5. Elimination 6. KineticsFollowing an Extravascular Dose 7. Absorption 8. ResponseFollowing a Single Dose III. Therapeutic Regimens 9. TherapeuticWindow 10. Constant-Rate Input 11. Multiple Dose Regimens IV.Individualization 12.Variability 13.Genetics 14. Age, Weight, andGender 15. Disease 16. Nonlinearities 17. Drug Interactions18. Initiating and Managing Therapy V. Supplemental Topics19. Distribution Kinetics 20. Metabolites and Drug Response 21. New!Protein Drugs 22. New! Prediction and Refinement of Human Kinetics from InVitro, Preclinical, and Early Clinical Data Appendices A. Assessment ofAUC B. Ionization and the pH Partition Hypothesis C. Distribution ofDrugs Extensively Bound to Plasma Proteins D. Plasma-to-BloodConcentration Ratio E. Well-stirred Model of Hepatic Clearance F.Absorption Kinetics G. Wagner-Nelson Method H. Mean Residence TimeI. Amount of Drug in Body on Accumulation to Plateau J. Answers to StudyProblems