目次

Introduction to Biopharmaceutics and PharmacokineticsBasic Mathematics for PharmacokineticsDrug Pharmacokinetics Following Single IV Bolus Administration: Drug DistributionDrug Pharmacokinetics Following Single IV Bolus Administration: Drug ClearanceDrug Pharmacokinetics Following Single IV Bolus Administration: The Drug Elimination RateDrug Absorption Following Oral Administration: Molecular and Physicochemical ConsiderationsDrug Absorption Following Oral Administration: Physiological and pathological ConsiderationsDrug Absorption Following Oral Administration: Formulation FactorsDrug Pharmacokinetics Following Single Oral Administration: The Rate of Drug AbsorptionDrug Pharmacokinetics Following Single Oral Administration: The Extent of Drug AbsorptionBioequivalenceDrug Pharmacokinetics During Constant Rate IV Infusion: The Steady State PrincipleSteady State During Multiple Drug AdministrationRenal Drug ExcretionMetabolite KineticsNonlinear PharmacokineticsMulticompartment Pharmacokinetic ModelsDrug Pharmacokinetics During Repeated Intermittent IV InfusionsPharmacokinetic-Pharmacodynamic RelationshipsNoncompartmental Approach in Data AnalysisPhysiological Approach to Drug ClearancePhysiological pharmacokinetic Modeling and Animal Scale UpTherapeutic Drug MonitoringPharmacokinetics in Special Patient PopulationPharmacokinetic Basis of Drug InteractionPharmacogenomics: The Genetic Basis of Pharmacokinetic VariabilityCommon Experimental Techniques in Pharmacokinetic StudiesComputers in PharmacokineticsSolutions to Practice Problems