This volume contains the proceedings of the 18th International Conference on Arithmetic, Geometry, Cryptography, and Coding Theory, held (online) from May 31 to June 4, 2021. For over thirty years, the biennial international conference AGC2 T Arithmetic, Geometry, Cryptography, and Coding Theory) has brought researchers together to forge connections between arithmetic geometry and its applications to coding theory and to cryptography. The papers illustrate the fruitful interaction between abstract theory and explicit computations, covering a large range of topics, including Belyi maps, Galois representations attached to elliptic curves, reconstruction of curves from their Jacobians, isogeny graphs of abelian varieties, hypergeometric equations, and Drinfeld modules.