【創薬と評価シリーズ:安全性と薬物動態試験 第2版 全2巻】
Drug Discovery and Evaluation 2nd ed.(Drug Discovery and Evaluation) hardcover 2 Vols., XXIV, 1404 p. 243 illus. 13
内容
目次
Safety PharmacokineticsAbsorption / in vitro Tests / Cell BasedAbsorption / in vitro Tests / Non Cell BasedAbsorption / in vivo Tests (Radiolabeled)Bioanalytical Assays - RIA/EIABioanalytical Assays / Gas Chromatography (GC)Bioanalytical Assays / LC-MS/MSBioanalytical Assays / ToxicokineticsClinical Studies / Typical DesignsDistribution - Across BarriersDistribution - in vivo - Perfused OrgansDistribution / in vitro Tests / Protein BindingDistribution / in vivo / Other MethodsDistribution in vivoDrug-drug Interaction / Enzyme InductionDrug-drug Interaction / Enzyme InhibitionIn silico ADME ModelingMetabolism Studies in vitro and in vivoPharmacogenomics in DMEPhysicochemical PropertiesPopulation PharmacokineticsSafety Pharmacokinetics: IntroductionTypical PK/PD Approaches in Preclinical and Clinical Development Safety PharmacologyAnalgesic Activity and Intravenous and Inhalation AnestheticsAnti-inflammatory and Antiarthrotic ActivityBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomicsAbsorption / in vitro Tests / Non Cell BasedAbsorption / in vivo Tests (Radiolabeled)Bioanalytical Assays - RIA/EIABioanalytical Assays / Gas Chromatography (GC)Bioanalytical Assays / LC-MS/MSBioanalytical Assays / ToxicokineticsClinical Studies / Typical DesignsDistribution - Across BarriersDistribution - in vivo - Perfused OrgansDistribution / in vitro Tests / Protein BindingDistribution / in vivo / Other MethodsDistribution in vivoDrug-drug Interaction / Enzyme InductionDrug-drug Interaction / Enzyme InhibitionIn silico ADME ModelingMetabolism Studies in vitro and in vivoPharmacogenomics in DMEPhysicochemical PropertiesPopulation PharmacokineticsSafety Pharmacokinetics: IntroductionTypical PK/PD Approaches in Preclinical and Clinical Development Safety PharmacologyAnalgesic Activity and Intravenous and Inhalation AnestheticsAnti-inflammatory and Antiarthrotic ActivityBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomicsBiomaterials in Their Role in Creating New Approaches for the Delivery of Drugs, Proteins, Nucleic acids, and Mammalian cellsBlood ConstituentsCardiovascular PharmacologyCentral Nervous SystemChronobiology and the Implications for Safety PharmacologyCochlear Safety TestsDrug Safety on Herbal Medical ProductsDrug-Addiction and Drug-DependencyEndocrine PharmacologyMagnetic Resonance Imaging and Imaging in Pharmaceutical Safety AssessmentMetabolism PharmacologyOcular Safety TestsOncology PharmacologyPeripheral Nervous SystemPulmonary PharmacologyRenal SystemSafe Chemicals / REACHSafety Pharmacology in Biologics, Antibiotics and MonoclonicsSafety Pharmacology: Introduction and GuidelinesSensory SystemsSkin PharmacologyStem Cells in Safety PharmacologyStudy design and statisticsTransgenic AnimalsZebrafish Model Safety ToxicologyGenotoxicityIn silico MethodsIn vitro toxicity testingInternational GuidelinesOMICS TechnologiesReproductive ToxicologySafety Toxicology: IntroductionTesting of Medical DevicesTesting of Monoclonal AntibodiesToxicogenomics
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