内容

目次

Part I is Online Only Clinical Evaluation 1 General Aspects of the Patient's Neurologic History e1 Kenneth F. Swaiman 2 Neurologic Examination of the Older Child e15 Kenneth F. Swaiman 3 Neurologic Examination after the Newborn Period until 2 Years of Age e33 Kenneth F. Swaiman and Lawrence W. Brown 4 Neurologic Examination of the Term and Preterm Infant e43 Kenneth F. Swaiman 5 Muscular Tone and Gait Disturbances e60 Kenneth F. Swaiman and Lawrence W. Brown 6 Vision Loss e71 Douglas R. Fredrick 7 Hearing Impairment e89 Isabelle Rapin and Oranee Sanmaneechai 8 Vertigo e118 Joseph M. Furman and Margaretha L. Casselbrant 9 Taste and Smell e126 Julie A. Mennella Part II is Online Only Neurodiagnostic Testing 10 Spinal Fluid Examination e140 David J. Michelson 11 Pediatric Neuroimaging e151 Nathaniel D. Wycliffe, Barbara A. Holshouser, and Stephen Ashwal 12 Pediatric Neurophysiologic Evaluation e185 Mark S. Scher Part III Emerging Neuroscience Concepts 13 Brain Plasticity and its Disorders 3 Michael V. Johnston 14 Neurodegeneration in the Neonatal Brain 13 Frances J. Northington and Lee J. Martin 15 Neuroinflammation 29 Pierre Gressens and Zinaida S. Vexler Part IV Perinatal Acquired and Congenital Neurologic Disorders 16 Neonatal Seizures 33 Frances E. Jensen and Faye S. Silverstein 17 Hypoxic-Ischemic Brain Injury in the Term Newborn 47 Steven P. Miller and Donna M. Ferriero 18 Neonatal Brain Injury 59 Adam Kirton, Linda S. de Vries, Lori Jordan, and Jerome Y. Yager 19 Injury to the Developing Preterm Brain: Intraventricular Hemorrhage and White Matter Injury 77 Laura R. Ment and Janet S. Soul 20 Perinatal Metabolic Encephalopathies 100 Rebecca N. Ichord Part V Congenital Structural Defects 21 Overview of Disorders of Brain Development 120 William B. Dobyns, Renzo Guerrini and A. James Barkovich 22 Disorders of Neural Tube Development 125 Nalin Gupta and M. Elizabeth Ross 23 Disorders of Forebrain Development 145 Elliott H. Sherr and Jin S. Hahn 24 Disorders of Cerebellar and Brainstem Development 160 Kathleen J. Millen and Joseph G. Gleeson 25 Disorders of Brain Size 173 Ghayda Mirzaa, Stephen Ashwal, and William B. Dobyns 26 Malformations of Cortical Development 202 William B. Dobyns, Renzo Guerrini, and Richard J. Leventer 27 Hydrocephalus and Arachnoid Cysts 232 James M. Drake and Amal Abou-Hamden 28 Congenital Anomalies of the Skull 247 Pedro A. Sanchez-Lara and John M. Graham, Jr. 29 Prenatal Diagnosis of Structural Brain Anomalies 263 Tally Lerman-Sagie, Gustavo Malinger, and Liat Ben-Sira Part VI Genetic, Metabolic, and Neurocutaneous Disorders 30 Introduction to Genetics 277 William B. Dobyns, Susan L. Christian and Soma Das 31 Chromosomes and Chromosomal Abnormalities 307 Maria Descartes, Bruce R. Korf and Fady M. Mikhail 32 Aminoacidemias and Organic Acidemias 328 Gregory M. Enns, Tina M. Cowan, Ophir Klein, and Seymour Packman 33 Inborn Errors of Urea Synthesis 357 Uta Lichter-Konecki and Mark L. Batshaw 34 Diseases Associated with Primary Abnormalities in Carbohydrate Metabolism 368 Marc C. Patterson and Kenneth F. Swaiman 35 Disorders of Glycosylation 390 Hudson H. Freeze and Marc C. Patterson 36 Lysosomal Storage Diseases 403 Gregory M. Pastores 37 Mitochondrial Diseases 452 Darryl C. De Vivo and Salvatore DiMauro 38 Peroxisomal Disorders 468 Gerald V. Raymond, Kristin W. Baranano, and S. Ali Fatemi 39 Neurotransmitter-Related Disorders 486 Matthew T. Sweney and Kathryn J. Swoboda 40 Phakomatoses and Allied Conditions 497 Elizabeth A. Thiele and Bruce R. Korf 41 Degenerative Disorders Primarily of Gray Matter 518 Rose-Mary N. Boustany and Mohamad K. El-Bitar 42 Channelopathies 544 Kelly Knupp, Julie A. Parsons, and Amy R. Brooks-Kayal Part VII Neurodevelopmental Disorders 43 Global Developmental Delay and Mental Retardation/Intellectual Disability 554 Elliott H. Sherr and Michael I. Shevell 44 Cognitive and Motor Regression 575 David J. Michelson and Stanford K. Shu 45 Developmental Language Disorders 604 Ruth Nass and Doris A. Trauner 46 Dyslexia 613 Sally E. Shaywitz and Bennett A. Shaywitz 47 Attention-Deficit Hyperactivity Disorder 622 David E. Mandelbaum 48 Autistic Spectrum Disorders 638 Deborah G. Hirtz, Ann Wagner and Pauline A. Filipek 49 Neuropsychopharmacology 664 Rebecca Rendleman and John T. Walkup Part VIII Epilepsy 50 Pediatric Epilepsy: An Overview 703 Peter R. Camfield and Carol S. Camfield 51 Neurophysiology of Seizures and Epilepsy 711 Carl E. Stafstrom and Jong M. Rho 52 Genetics of Epilepsy 727 Maria Roberta Cilio and Susannah Cornes 53 Generalized Seizures 736 Gregory L. Holmes 54 Focal and Multifocal Seizures 751 Douglas R. Nordli, Jr. 55 Epilepsy and Neurodevelopmental Disorders 767 Roberto Tuchman 56 Myoclonic Seizures and Infantile Spasms 774 Kendall Nash and Joseph Sullivan 57 Febrile Seizures 790 Shlomo Shinnar 58 Status Epilepticus 798 Lawrence D. Morton and John M. Pellock 59 Antiepileptic Drug Therapy in Children 811 Jeannine M. Conway, Ilo E. Leppik, and Angela K. Birnbaum 60 The Ketogenic Diet 836 James W. Wheless 61 Epilepsy Surgery in the Pediatric Population 854 Mary L. Zupanc and Charles J. Marcuccilli 62 Behavioral, Cognitive, and Social Aspects of Childhood Epilepsy 871 Wendy G. Mitchell, Miche`le Van Hirtum-Das, Jay Desai, and Quyen N. Luc Part IX Nonepileptiform Paroxysmal Disorders and Disorders of Sleep 63 Headaches in Infants and Children 880 Donald W. Lewis 64 Breath-Holding Spells and Reflex Anoxic Seizures 900 Sarah M. Roddy 65 Syncope and Paroxysmal Disorders Other than Epilepsy 905 Neil R. Friedman, Debabrata Ghosh, and Manikum Moodley 66 Sleep-Wake Disorders 926 Suresh Kotagal Part X Disorders of Balance and Movement 67 The Cerebellum and the Hereditary Ataxias 939 Paymaan Jafar-Nejad, Stephen M. Maricich, and Huda Y. Zoghbi 68 Movement Disorders 965 Terence D. Sanger and Jonathan W. Mink 69 Cerebral Palsy 999 Kenneth F. Swaiman and Yvonne W. Wu 70 Tics and Tourette's Syndrome 1009 Harvey S. Singer Part XI White Matter Disorders 71 Genetic and Metabolic Disorders of the White Matter 1020 Adeline Vanderver and Nicole I. Wolf 72 Acquired Disorders affecting the White Matter 1052 Naila Makhani and Brenda Banwell Part XII Brain Injury and Disorders of Consciousness 73 Impairment of Consciousness and Coma 1062 Donald A. Taylor and Stephen Ashwal 74 Traumatic Brain Injury in Children 1087 Jason T. Lerner and Christopher C. Giza 75 Non-accidental Head Trauma 1126 Elizabeth E. Gilles and Ann-Christine Duhaime 76 Hypoxic-Ischemic Encephalopathy in Infants and Older Children 1149 Ronald M. Perkin and Stephen Ashwal 77 Disorders of Intracranial Pressure 1185 Mark S. Wainwright 78 Spinal Cord Injury 1198 N. Paul Rosman and Chellamani Harini 79 Determination of Brain Death in Infants and Children 1221 Stephen Ashwal Part XIII Infections of the Nervous System 80 Bacterial Infections of the Nervous System 1241 Martin G. Ta¨uber and Urs B. Schaad 81 Viral Infections of the Nervous System 1262 James F. Bale, Jr. 82 Fungal, Rickettsial, and Parasitic Diseases of the Nervous System 1291 Carol A. Glaser, Paul F. Lewis, and Janice K. Louie Part XIV Tumors and Vascular Disorders of the Nervous System 83 Tumors of the Brain and Spine 1339 Roger J. Packer, Tobey J. MacDonald, and Gilbert Vezina 84 Paraneoplastic Syndromes Affecting the Nervous System 1388 Mustafa Khasraw and Yasmin Khakoo 85 Cerebrovascular Disease in Children 1395 Adam Kirton and Gabrielle deVeber 86 Neurologic Manifestations of Rheumatic Disorders of Childhood 1437 Nina Felice Schor, Emily von Scheven, and Stephen Ashwal Part XV Neuromuscular Disorders 87 Normal Muscle 1463 V. Venkataraman Vedanarayanan and Owen B. Evans, Jr. 88 Anterior Horn Cell and Cranial Motor Neuron Disease 1482 Ching H. Wang and Anne M. Connolly 89 Peripheral Neuropathies 1503 Stephen A. Smith and Robert Ouvrier 90 Inflammatory Neuropathies 1532 John T. Sladky and Stephen Ashwal 91 Diseases of the Neuromuscular Junction 1549 Srikanth Muppidi, Gil I. Wolfe, and Richard J. Barohn 92 Muscular Dystrophies 1570 Diana M. Escolar and Robert T. Leshner 93 Congenital Myopathies 1607 Jonathan B. Strober 94 Metabolic Myopathies 1613 Ingrid Tein 95 Inflammatory Myopathies 1658 Anthony A. Amato and John T. Kissel 96 Channelopathies: Myotonic Disorders and Periodic Paralysis 1667 Richard T. Moxley III and Chad Heatwole Part XVI Systemic and Autonomic Nervous System Diseases 97 Endocrine Disorders of the Hypothalamus and Pituitary in Childhood and Adolescence 1690 Qing Dong and Stephen M. Rosenthal 98 Disorders of the Autonomic Nervous System: Autonomic Dysfunction in Pediatric Practice 1703 Felicia B. Axelrod 99 Disorders of Micturition and Defecation 1720 Jennifer A. Zimmer and Bhuwan P. Garg 100 Poisoning and Drug-Induced Neurologic Diseases 1731 Laurence E. Walsh and Bhuwan P. Garg 101 Neurologic Disorders in Children with Heart Disease 1758 Catherine Limperopoulos and Adre´ J. du Plessis 102 Interrelationships between Renal and Neurologic Diseases and Therapies 1782 Robert S. Rust 103 Neurologic Disorders Associated with Gastrointestinal Diseases and Nutritional Deficiencies 1821 Yitzchak Frank and Stephen Ashwal 104 Neurologic Complications of Immunization 1867 Claudia A. Chiriboga Part XVII is Online Only Care of the Child with Neurologic Disorders 105 Pediatric Neurorehabilitation Medicine e234 Michael J. Noetzel 106 Pain Management and Palliative Care e250 John Colin Partridge 107 Ethical Issues in Child Neurology e264 David L. Coulter 108 The Impact of Computer Resources on Child Neurology e275 Michael M. Segal and Steven Leber Index i1