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SECTION I: ETIOLOGY, PREVENTION, AND MOLECULAR BIOLOGY 1 Epidemiology of Gynecologic Cancers 1 2 Molecular Pathogenesis of Gynecologic Cancers 30 3 Hereditary Gynecologic Cancers 60 4 Invasion, Metastasis, and Angiogenesis 72 5 Development and Identification of Tumor Serum Markers 89 6 Cancer Prevention Strategies 115 7 Preinvasive Disease of the Lower Genital Tract 129 SECTION II: DIAGNOSTIC AND THERAPEUTIC MODALITIES 8 Perioperative and Critical Care 151 9 Surgical Principles in Gynecologic Oncology 190 10 Minimally Invasive Surgery in Gynecologic Cancer 210 11 Diagnostic Imaging 244 12 Biologic and Physical Principles of Radiation Oncology 284 13 Principles of Chemotherapy in Gynecologic Cancer 342 14 Pharmacology and Therapeutics in Gynecologic Cancer 370 15 Immunotherapy of Gynecologic Malignancies 434 16 Hormones and Human Malignancies 457 17 Clinical Trials Methodology and Biostatistics 481 18 Comparative Effectiveness Research in Gynecologic Oncology 501 SECTION III: DISEASE SITES 19 Vulva 523 20 Vagina 557 21 Cervix 598 22 Corpus: Epithelial Tumors 661 23 Corpus: Mesenchymal Tumors 715 24 Epithelial Ovarian Cancer 757 25 Ovarian Germ Cell Tumors 848 26 Ovarian Sex Cord—Stromal Tumors 866 27 Gestational Trophoblastic Disease: Molar Pregnancy and Gestational Trophoblastic Neoplasia 886 SECTION IV: SPECIAL MANAGEMENT TOPICS 28 Breast Cancer 909 29 Management of Infections in Patients with Gynecologic Malignancy 967 30 Management of Acute and Chronic Complications of Gynecologic Cancer Treatment 988 31 Management of Pain 1003 32 Nutrition Support of Patients with Gynecologic Cancer 1025 33 Quality-of-Life Issues in Gynecologic Oncology 1039 34 End-of-Life Care 1052 Index 1065