内容

目次

Part I Analyzing DNA RNA and Protein Sequences 1 Introduction 3 2 Access to Sequence Data and Related Information 19 3 Pairwise Sequence Alignment 69 4 Basic Local Alignment Search Tool (BLAST) 121 5 Advanced Database Searching 167 6 Multiple Sequence Alignment 205 7 Molecular Phylogeny and Evolution 245 Part II Genomewide Analysis of DNA RNA and Protein 8 DNA: The Eukaryotic Chromosome 307 9 Analysis of Next–Generation Sequence Data 377 10 Bioinformatic Approaches to Ribonucleic Acid (RNA) 433 11 Gene Expression: Microarray and RNA–seq Data Analysis 479 12 Protein Analysis and Proteomics 539 13 Protein Structure 589 14 Functional Genomics 635 Part III Genome Analysis 15 Genomes Across the Tree of Life 699 16 Completed Genomes: Viruses 755 17 Completed Genomes: Bacteria and Archaea 797 18 Eukaryotic Genomes: Fungi 847 19 Eukaryotic Genomes: From Parasites to Primates 887 20 Human Genome 957 21 Human Disease 1011 GLOSSARY 1075 Self–Test Quiz: Solutions 1103 Author Index 1105 Subject Index 1109