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VOLUME 1 PART 1 SCIENTIFIC PRINCIPLES OF RESPIRATORY MEDICINE SECTION A: Anatomy and Development of the Respiratory Tract 1 Anatomy of the Lungs 2 Lung Growth and Development 3 Genetics of Lung Disease SECTION B: Respiratory Physiology 4 Ventilation, Blood Flow, and Gas Exchange 5 Respiratory System Mechanics and Energetics 6 Pulmonary Circulation and Regulation of Fluid Balance 7 Acid-Base Balance SECTION C: Defense Mechanisms and Immunology 8 Alveolar Epithelium and Pulmonary Surfactant 9 Alveolar Epithelium and Fluid Transport 10 Airway Epithelium and Mucous Secretion 11 Aerosol Deposition and Clearance 12 Innate Immunity 13 Adaptive Immunity SECTION D: Respiratory Pathology and Inflammation 14 Pathology: Malignant and Interstitial Lung Diseases 15 Injury and Repair PART 2 DIAGNOSIS AND EVALUATION OF RESPIRATORY DISEASE SECTION E: Diagnosis 16 History and Physical Examination 17 Microbiologic Diagnosis of Lung Infection 18 Thoracic Radiology: Noninvasive Diagnostic Imaging 19 Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions 20 Ultrasonography 21 Positron Emission Tomography 22 Diagnostic Bronchoscopy 23 Therapeutic Bronchoscopy 24 Thoracoscopy SECTION F: Evaluation 25 Pulmonary Function Testing 26 Clinical Exercise Testing 27 Preoperative Evaluation 28 Evaluation of Respiratory Impairment and Disability PART 3 CLINICAL RESPIRATORY MEDICINE SECTION G: Symptoms of Respiratory Disease and Their Management 29 Dyspnea 30 Cough 31 Chest Pain SECTION H: Infectious Diseases of the Lungs 32 Viral Infections 33 Bacterial Pneumonia and Lung Abscess 34 Ventilator-Associated Pneumonia 35 Tuberculosis 36 Nontuberculous Mycobacterial Infections 37 Endemic Mycoses 38 Opportunistic Mycoses 39 Parasitic Infections 40 Bioterrorism SECTION I: Obstructive Diseases 41 Asthma: Pathogenesis and Phenotypes 42 Asthma: Clinical Diagnosis and Management 43 COPD: Pathogenesis and Natural History 44 COPD: Clinical Diagnosis and Management 45 Genetics in Asthma and COPD 46 Smoking Hazards and Cessation 47 Cystic Fibrosis 48 Bronchiectasis 49 Upper Airway Disorders 50 Bronchiolitis and Other Intrathoracic Airway Disorders VOLUME 2 SECTION J: Neoplasms of the Lung 51 Biology of Lung Cancer 52 Epidemiology of Lung Cancer 53 Clinical Aspects of Lung Cancer 54 Rare Primary Lung Tumors 55 Metastatic Malignant Tumors 56 Benign Lung Tumors SECTION K: Disorders of the Pulmonary Circulation 57 Pulmonary Thromboembolism 58 Pulmonary Hypertension 59 Pulmonary Hypertension due to Lung Disease 60 Pulmonary Vasculitis 61 Pulmonary Vascular Abnormalities 62 Pulmonary Edema SECTION L: Infiltrative and Interstitial Lung Diseases 63 Idiopathic Interstitial Pneumonias 64 Hypersensitivity Pneumonitis 65 Connective Tissue Diseases 66 Sarcoidosis 67 Alveolar Hemorrhage and Rare Infiltrative Diseases 68 Eosinophilic Lung Diseases 69 Lymphangioleiomyomatosis 70 Pulmonary Alveolar Proteinosis Syndrome 71 Drug-Induced Pulmonary Disease SECTION M: Environmental and Occupational Hazards 72 Asthma in the Workplace 73 Pneumoconioses 74 Indoor and Outdoor Air Pollution 75 Acute Responses to Toxic Exposures 76 Trauma and Blast Injuries 77 High Altitude 78 Diving Medicine SECTION N: Disorders of the Pleura 79 Pleural Effusion 80 Pleural Infections 81 Pneumothorax, Chylothorax, Hemothorax, and Fibrothorax 82 Pleural Tumors SECTION O: Disorders of the Mediastinum 83 Mediastinal Tumors and Cysts 84 Pneumomediastinum and Mediastinitis SECTION P: Disorders of Sleep and Control of Breathing 85 Control of Breathing and Upper Airways During Sleep 86 Hypocapnia and Hypercapnia 87 Consequences of Sleep Disruption 88 Obstructive Sleep Apnea 89 Central Sleep Apnea SECTION Q: Respiratory Manifestations of Extrapulmonary Disorders 90 Pulmonary Complications of HIV Infection 91 Pulmonary Complications of Stem Cell and Solid Organ Transplantation 92 Pulmonary Complications of Primary Immunodeficiencies 93 Pulmonary Complications of Abdominal Diseases 94 Pulmonary Complications of Hematologic Diseases 95 Pulmonary Complications of Endocrine Diseases 96 The Lungs in Obstetric and Gynecologic Diseases 97 The Respiratory System and Neuromuscular Diseases 98 The Respiratory System and Chest Wall Diseases SECTION R: Management of Respiratory Failure 99 Acute Ventilatory Failure 100 Acute Hypoxemic Respiratory Failure and ARDS 101 Mechanical Ventilation 102 Noninvasive Ventilation 103 Extracorporeal Support of Gas Exchange 104 End-of-Life Care in Respiratory Failure 105 Pulmonary Rehabilitation 106 Lung Transplantation