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Contributors, xi Preface to the First Edition, xvii Preface to the Fifth Edition, xviii Tribute, xix List of Abbreviations, xxii Section 1: History and Use of Hematopoietic Cell Transplantation 1 A History of Allogeneic and Autologous Hematopoietic Cell Transplantation, 1Karl G. Blume and E. Donnall Thomas 2 Uses and Growth of Hematopoietic Cell Transplantation, 8Mary M. Horowitz Section 2: Scientific Basis or Hematopoietic Cell Transplantation Section 2a: Hematopoiesis and Stem Biology Transplantation 3 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Pluripotent Stem Cells, 16Laurence Dahéron and David T. Scadden 4 Hematopoietic Stem Cells, Regenerative Medicine, and Leukemogenesis, 25Irving Weissman 5 Marrow Microenvironment and Biology of Mobilization of Stem Cells, 50Michael P. Rettig, Mark A. Schroeder and John F. DiPersio 6 Expansion of Human Hematopoietic Stem Cells, 62Colleen Delaney 7 Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation, 69Edwin M. Horwitz 8 Genetic Manipulation of Hematopoietic Stem Cells, 78Jennifer E. Adair, Grant D. Trobridge and Hans–Peter Kiem Section 2b: Immunology 9 Overview of Hematopoietic Cell Transplantation Immunology, 96Paul J. Martin and Warren D. Shlomchik 10 Histocompatibility, 112Effie W. Petersdorf 11 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation, 126Michael R. Verneris and Jeffrey S. Miller 12 Mechanisms of Tolerance, 136Defu Zeng and Samuel Strober 13 The Pathophysiology of Graft–versus–Host Disease, 146James L.M. Ferrara and Joseph H. Antin 14 Immune Regulation in Hematopoietic Cell Transplantation, 153Robert S. Negrin and Jerome Ritz 15 Immune Reconstitution Following Hematopoietic Cell Transplantation, 160Jarrod A. Dudakov, Miguel–Angel Perales and Marcel R.M. van den Brink 16 Biology of the Human Graft–versus–Tumor Response and How to Exploit It, 166Edus H. Warren 17 Dendritic Cells in Hematopoietic Cell Transplantation, 178Miriam Merad and Edgar G. Engleman 18 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 191Judith A. Shizuru Section 2c: Technical Aspects 19 Pharmacologic Basis for High–dose Chemotherapy, 211Borje S. Andersson, Benigno C. Valdez and Roy B. Jones 20 High–dose Preparatory Regimens, 223William I. Bensinger 21 Reduced–intensity Allogeneic Transplantation Regimens, 232Brenda M. Sandmaier and Rainer Storb 22 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 244Jeffrey Y.C. Wong and Timothy Schultheiss 23 Radioimmunotherapy and Hematopoietic Cell Transplantation, 258John M. Pagel and Ajay K. Gopal 24 Documentation of Engraftment and Characterization of Chimerism After Hematopoietic Cell Transplantation, 272Paul J. Martin 25 The Detection and Significance of Minimal Residual Disease, 281Merav Bar and Jerald P. Radich 26 Pathology of Hematopoietic Cell Transplantation, 292Keith R. Loeb, Cecilia C. Yeung and Howard M. Shulman 27 Biostatistical Methods in Hematopoietic Cell Transplantation, 329Joycelynne M. Palmer and Ted A. Gooley 28 Outcomes Research in Hematopoietic Cell Transplantation, 341Stephanie J. Lee Section 3: Patient–oriented Issues in Hematopoietic Cell Transplantation 29 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 349Bart L. Scott and Brenda M. Sandmaier 30 Nursing Role in Hematopoietic Cell Transplantation, 362Rosemary C. Ford, Mihkaila M. Wickline and Diane Heye 31 Ethical Issues in Hematopoietic Cell Transplantation, 374David S. Snyder 32 Psychosocial Issues in Hematopoietic Cell Transplantation, 384Richard P. McQuellon and Katharine E. Duckworth 33 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients, 392Karen L. Syrjala and Samantha Burns Artherholt 34 Sexuality Following Hematopoietic Cell Transplantation, 399D. Kathryn Tierney 35 Hematopoietic Cell Transplantation: The Patient's Perspective, 407Susan K. Stewart Section 4: Sources of Hematopoietic Cell for Hematopoietic Cell Transplantation 36 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation, 414Phyllis I. Warkentin and Elizabeth J. Shpall 37 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries, 423Dennis L. Confer, John P. Miller and Jeffrey W. Chell 38 The Role of the Transplant Program in a Nuclear Accident or Terrorism, 431Nelson J. Chao and Dennis L. Confer 39 Cord Blood Hematopoietic Cell Transplantation, 437Hal E. Broxmeyer, Sherif S. Farag and Vanderson Rocha 40 Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT, 452Thomas C. Shea and John F. DiPersio 41 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation, 460Norbert Schmitz and Peter Dreger 42 Cryopreservation of Hematopoietic Cells, 469Scott D. Rowley 43 Use of Recombinant Growth Factors after Hematopoietic Cell Transplantation, 480Jürgen Finke and Roland Mertelsmann 44 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors, 489Claudio Anasetti, Franco Aversa and Andrea Velardi 45 Hematopoietic Cell Transplantation from Unrelated Donors, 505Effie W. Petersdorf Section 5: Hematopoietic Cell Transplantation for Acquired Disease 46 Hematopoietic Cell Transplantation for Aplastic Anemia, 517George E. Georges and Rainer Storb 47 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, 537Ryotaro Nakamura 48 Hematopoietic Stem Cell Transplantation for Chronic Myeloid Leukemia, 545Jerald P. Radich and Ravi Bhatia 49 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia, 554Charlotte M. Niemeyer and Franco Locatelli 50 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia, 563Frederick R. Appelbaum 51 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia, 576Michael A. Pulsipher, Meghann McManus and Soheil Meshinchi 52 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults, 588Stephen J. Forman 53 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children, 600Parinda A. Mehta and Stella M. Davies 54 Hematopoietic Cell Transplantation for Myelodysplastic Syndromes and Myeloproliferative Neoplasms, 613H. Joachim Deeg 55 Hematopoietic Cell Transplantation for Multiple Myeloma, 625Amrita Krishnan and Sergio A. Giralt 56 Hematopoietic Cell Transplantation for Hodgkin Disease, 636Philip J. Bierman and Auayporn Nademanee 57 Hematopoietic Cell Transplantation for Non–Hodgkin Lymphoma (B Cell), 653Leslie L. Popplewell and Ginna G. Laport 58 Hematopoietic Cell Transplantation for Non–Hodgkin Lymphoma (T Cell), 664Jasmine Zain and Sandra H. Thomas 59 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia, 675Aaron C. Logan and David B. Miklos 60 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL–) Amyloidosis, 685Heather J. Landau, Morie A. Gertz and Raymond L. Comenzo 61 Autologous Hematopoietic Cell Transplantation for Breast Cancer and Germ–cell Tumors, 700Yago Nieto and Elizabeth J. Shpall 62 Hematopoietic Cell Transplantation for Renal Cell Carcinoma and Other Solid Tumors, 709Richard W. Childs and Ramaprasad Srinivasan 63 Hematopoietic Cell Transplantation for Neuroblastoma, 721Justin T. Wahlstrom and Katherine K. Matthay 64 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors, 729Masanori Hayashi, David M. Loeb and Allen R. Chen 65 Hematopoietic Cell Therapy for Human Immunodeficiency Virus Infection, 742Amrita Krishnan, Joseph Alvarnas, John J. Rossi and John A. Zaia 66 Hematopoietic Cell Transplantation for Autoimmune Diseases, 753Richard A. Nash 67 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies, 765Vinod Pullarkat and Stephen J. Forman 68 Adoptive T–cell Therapy for Viral Disease in the Setting of Hematopoietic Cell Transplantation, 777Catherine M. Bollard and Helen E. Heslop 69 Adoptive T–cell Therapy for Malignancy in the Setting of Hematopoietic Cell Transplantation, 787Stephen J. Forman, Michael Kalos and Carl H. June 70 Relapse of Hematologic Malignancy After Allogeneic Hematopoietic Transplantation, 797Richard Champlin Section 6: Hematopoietic Cell Transplantation for Inherited Disease 71 Hematopoietic Cell Transplantation for Thalassemia, 803Guido Lucarelli and Javid Gaziev 72 Hematopoietic Cell Transplantation for Sickle Cell Disease, 814Mark C. Walters 73 Hematopoietic Cell Transplantation for Immunodeficiency Diseases, 827Richard J. O'Reilly and Wilhelm Friedrich 74 Hematopoietic Cell Transplantation for Storage Diseases, 846Joseph Rosenthal 75 Hematopoietic Cell Transplantation for Macrophage, Granulocyte and Osteoclast, Disorders, 871Rajni Agarwal 76 Hematopoietic Cell Transplantation for Fanconi Anemia, 884John E. Wagner, Jakub Tolar, Arleen D. Auerbach and Margaret L. MacMillan Section 7: Complications of Hematopoietic Cell Transplantation 77 Mechanisms and Treatment of Graft Failure, 905Robert Lowsky and Hans Messner 78 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation, 916Margaret R. O'Donnell 79 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation, 922Jeffrey McCullough 80 Vascular Access and Complications, 937I. Benjamin Paz 81 Pharmacologic Prevention of Acute Graft–versus–Host Disease, 951Nelson J. Chao 82 T–cell Depletion to Prevent Graft–versus–Host Disease, 965Robert J. Soiffer 83 Manifestations and Treatment of Acute Graft–versus–Host Disease, 973Corey Cutler and Joseph H. Antin 84 Chronic Graft–versus–Host Disease ??? Clinical Manifestations and Therapy, 981Paul A. Carpenter, Mary E.D. Flowers and Steven Z. Pavletic 85 Bacterial Infections, 999Helen L. Leather and John R. Wingard 86 Fungal Infections After Hematopoietic Cell Transplantation, 1018Kieren A. Marr 87 Cytomegalovirus Infection, 1030John A. Zaia 88 Herpes Simplex Virus Infections, 1039Sanjeet S. Dadwal and James I. Ito 89 Varicella Zoster Virus Infections, 1046Dora Y. Ho and Ann M. Arvin 90 Epstein???Barr Virus Infection, 1066Jennifer A. Kanakry and Richard F. Ambinder 91 Respiratory Viruses After Hematopoietic Cell Transplantation, 1073Sachiko Seo and Michael Boeckh 92 HHV–6A, HHV–6B, HHV–7, and HHV–8 After Hematopoietic Cell Transplantation, 1083Per Ljungman, Tetsushi Yoshikawa and Katherine N. Ward 93 Human Adenovirus, Polyomavirus, and Parvovirus Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation, 1090Hans H. Hirsch and Steven A. Pergam 94 Gastrointestinal and Hepatic Complications, 1101David M. Hockenbery, Simone I. Strasser and George B. McDonald 95 Lung Injury Following Hematopoietic Cell Transplantation, 1117Kenneth R. Cooke and Gregory A. Yanik 96 Kidney and Bladder Complications of Hematopoietic Cell Transplantation, 1131Sangeeta Hingorani 97 Endocrine Complications Following Hematopoietic Cell Transplantation, 1142Fouad R. Kandeel and Behrouz Salehian 98 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation, 1167Anne Poon and Lowan K. Ly 99 Nutrition Support of the Hematopoietic Cell Transplant Recipient, 1177Paula Charuhas Macris and Kerry K. McMillen 100 Pain Management, 1186Noelle V. Frey and Jonathan R. Gavrin 101 Oral Complications of Hematopoietic Cell Transplantation, 1203Mark M. Schubert, Maria Elvira Pizzigatti Correa and Douglas E. Peterson 102 Growth and Development After Hematopoietic Cell Transplantation, 1218K. Scott Baker and Anna Petryk 103 Delayed Non–malignant Complications After Hematopoietic Cell Transplantation, 1227Smita Bhatia 104 Subsequent Malignant Neoplasms After Hematopoietic Cell Transplantation, 1236Smita Bhatia and Ravi Bhatia 105 Neurologic Complications of Hematopoietic Cell Transplantation, 1248Harry Openshaw and Bihong T. Chen 106 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients, 1258Trudy N. Small Index, 1266