内容

目次

Part I: Clinical Evaluation of the Patient 1: Initial Approach to the Patient: History and Physical Examination 2: Examination of Blood Cells 3: Examination of the Marrow 4: Consultative Hematology Part II: The Organization of the Lymphohematopoietic Tissues 5: Structure of the Marrow and the Hematopoietic Microenvironment 6: The Organization and Structure of Lymphoid Tissues Part III: Epochal Hematology 7: Hematology of the Fetus and Newborn 8: Hematology During Pregnancy 9: Hematology in Older Persons Part IV: Molecular and Cellular Hematology 10: Genetic Principles and Molecular Biology 11: Genomics 12: Epigenetics 13: Cytogenetics and Genetic Abnormalities 14: Metabolism of Hematologic Neoplastic Cells 15: Apoptosis Mechanisms: Relevance to the Hematopoietic System 16: Cell-Cycle Regulation and Hematologic Disorders 17: Signal Transduction Pathways 18: Hematopoietic Stem Cells, Progenitors, and Cytokines 19: The Inflammatory Response 20: Innate Immunity 21: Dendritic Cells and Adaptive Immunity Part V: Therapeutic Principles 22: Pharmacology and Toxicity of Antineoplastic Drugs 23: Hematopoietic Cell Transplantation 24: Treatment of Infections in the Immunocompromised Host 25: Principles of Antithrombotic Therapy 26: Immune Cell Therapy 27: Vaccine Therapy 28: Therapeutic Apheresis: Indications, Efficacy, and Complications 29: Gene Therapy for Hematologic Diseases 30: Regenerative Medicine: Multipotential Cell Therapy for Tissue Repair Part VI: The Erythrocyte 31: Structure and Composition of the Erythrocyte 32: Erythropoiesis 33: Erythrocyte Turnover 34: Clinical Manifestations and Classification of Erythrocyte Disorders 35: Aplastic Anemia: Acquired and Inherited 36: Pure Red Cell Aplasia 37: Anemia of Chronic Disease 38: Erythropoietic Effects of Endocrine Disorders 39: The Congenital Dyserythropoietic Anemias 40: Paroxysmal Nocturnal Hemoglobinuria 41: Folate, Cobalamin, and Megaloblastic Anemias 42: Iron Metabolism 43: Iron Deficiency and Overload 44: Anemia Resulting from other Nutritional Deficiencies 45: Anemia Associated with Marrow Infiltration 46: Erythrocyte Membrane Disorders 47: Erythrocyte Enzyme Disorders 48: The Thalassemias: Disorders of Globin Synthesis 49: Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities 50: Methemoglobinemia and Other Dyshemoglobinemias 51: Fragmentation Hemolytic Anemia 52: Erythrocyte Disorders as a Result of Chemical and Physical Agents 53: Hemolytic Anemia Resulting from Infections with Microorganisms 54: Hemolytic Anemia Resulting from Immune Injury 55: Alloimmune Hemolytic Disease of the Fetus and Newborn 56: Hypersplenism and Hyposplenism 57: Primary and Secondary Erythrocytoses 58: The Porphyrias 59: Polyclonal and Hereditary Sideroblastic Anemias Part VII: Neutrophils, Eosinophils, Basophils, and Mast Cells 60: Structure and Composition of Neutrophils, Eosinophils, and Basophils 61: Production, Distribution, and Fate of Neutrophils 62: Eosinophils and Related Disorders 63: Basophils, Mast Cells, and Related Disorders 64: Classification and Clinical Manifestations of Neutrophil Disorders 65: Neutropenia and Neutrophilia 66: Disorders of Neutrophil Function Part VIII: Monocytes and Macrophages 67: Structure, Receptors, and Functions of Monocytes and Macrophages 68: Production, Distribution, and Activation of Monocytes and Macrophages 69: Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages 70: Monocytosis and Monocytopenia 71: Inflammatory and Malignant Histiocytosis 72: Gaucher Disease and Related Lysosomal Storage Diseases Part IX: Lymphocytes and Plasma Cells 73: The Structure of Lymphocytes and Plasma Cells 74: Lymphopoiesis 75: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production 76: Functions of Tlymphocytes: T-Cell Receptors for Antigen 77: Functions of Natural Killer Cells 78: Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders 79: Lymphocytosis and Lymphocytopenia 80: Immunodeficiency Diseases 81: Hematologic Manifestations of Acquired Immunodeficiency Syndrome 82: Mononucleosis Syndromes Part X: Malignant Myeloid Diseases 83: Classification and Clinical Manifestations of the Clonal Myeloid Disorders 84: Polycythemia Vera 85: Essential Thrombocythemia 86: Primary Myelofibrosis 87: Myelodysplastic Syndromes Updated! 88: Acute Myelogenous Leukemia 89: Chronic Myelogenous Leukemia and Related Disorders Part XI: Malignant Lymphoid Diseases 90: Classification of Malignant Lymphoid Disorders 91: Acute Lymphoblastic Leukemia 92: Chronic Lymphocytic Leukemia 93: Hairy Cell Leukemia 94: Large Granular Lymphocytic Leukemia 95: General Considerations for Lymphomas: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease 96: Pathology of Lymphomas 97: Hodgkin Lymphoma 98: Diffuse Large B-Cell Lymphoma and Related Diseases 99: Follicular Lymphoma 100: Mantle Cell Lymphoma 101: Marginal Zone B-Cell Lymphomas 102: Burkitt Lymphoma 103: Cutaneous T-Cell Lymphoma (Mycosis Fungoides and SéZary Syndrome) 104: Mature T-Cell and Natural Killer Cell Lymphomas 105: Plasma Cell Neoplasms: General Considerations 106: Essential Monoclonal Gammopathy 107: Myeloma 108: Immunoglobulin Light-Chain Amyloidosis 109: Macroglobulinemia 110: Heavy-Chain Disease Part XII: Hemostasis and Thrombosis 111: Megakaryopoiesis and Thrombopoiesis 112: Platelet Morphology, Biochemistry, and Function 113: Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis 114: Control of Coagulation Reactions 115: Vascular Function in Hemostasis 116: Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis 117: Thrombocytopenia 118: Heparin-Induced Thrombocytopenia 119: Reactive Thrombocytosis 120: Hereditary Qualitative Platelet Disorders 121: Acquired Qualitative Platelet Disorders 122: The Vascular Purpuras 123: Hemophilia A and Hemophilia B 124: Inherited Deficiencies of Coagulation Factors II, V, V+VIII, VII, X, XI, and XIII 125: Hereditary Fibrinogen Abnormalities 126: Von Willebrand Disease 127: Antibody-Mediated Coagulation Factor Deficiencies 128: Hemostatic Alterations in Liver Disease and Liver Transplantation 129: Disseminated Intravascular Coagulation 130: Hereditary Thrombophilia 131: The Antiphospholipid Syndrome 132: Thrombotic Microangiopathies 133: Venous Thrombosis 134: Atherothrombosis: Disease Initiation, Progression, and Treatment 135: Fibrinolysis and Thrombolysis Part XIII: Transfusion Medicine 136: Erythrocyte Antigens and Antibodies 137: Human Leukocyte and Platelet Antigens 138: Blood Procurement and Red Cell Transfusion 139: Preservation and Clinical Use of Platelets