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Part I: Introduction Hematopoiesis and Bone Marrow Histology Bone Marrow Examination and Techniques Bone Marrow Reporting Overview of Constitutional and Acquired Bone Marrow Disorders Part II: Anemia Overview of Anemia SECTION 1: ACQUIRED ANEMIAS Iron Deficiency Anemia Autoimmune Hemolytic Anemias Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn Microangiopathic Hemolytic Anemia Megaloblastic Anemia Acquired Nonneoplastic Sideroblastic Anemia Alcoholism-Associated Anemia Anemia in the Elderly Copper Deficiency-Associated Anemia Acquired Red Cell Aplasia Transient Erythroblastopenia of Childhood Parvovirus-Induced Red Cell Aplasia Paroxysmal Nocturnal Hemoglobinuria Acquired Aplastic Anemia SECTION 2: CONSTITUTIONAL ANEMIAS Thalassemia Sickle Cell Anemia Pyruvate Kinase Deficiency Hereditary Spherocytosis Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis Diamond-Blackfan Anemia Fanconi Anemia Congenital Dyserythropoietic Anemia Congenital Sideroblastic Anemia Congenital Megaloblastic Anemia Part III: Erythrocytosis SECTION 1: CONSTITUTIONAL Congenital Erythrocytosis SECTION 2: ACQUIRED Acquired Erythrocytosis Part IV: Benign Leukocyte Disorders in Blood and Bone Marrow Overview of Benign Leukocyte Disorders in Blood and Bone Marrow Pancytopenia Neutropenia Neutrophilia Monocytosis Eosinophilia Basophilia Lymphocytosis Lymphopenia, Constitutional and Acquired Plasmacytosis of Bone Marrow Hematogones in Bone Marrow Lymphoid Aggregates in Bone Marrow Granulomas in Bone Marrow Part V: Constitutional Granulocytic Disorders SECTION 1: CONSTITUTIONAL NEUTROPENIAS Severe Congenital Neutropenia and Cyclic Neutropenia Shwachman-Diamond Syndrome Chediak-Higashi Syndrome Myelokathexis in WHIM Syndrome SECTION 2: CONSTITUTIONAL NEUTROPHIL ANOMALIES Pelger-Huet Anomaly MYH9-Related Disorders Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation Part VI: Megakaryocytic Disorders Overview of Megakaryocytic Disorders SECTION 1: ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA Immune-Mediated Thrombocytopenia Hemolytic-Uremic Syndrome Thrombotic Thrombocytopenic Purpura Pregnancy-Associated Thrombocytopenia SECTION 2: CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA Thrombocytopenia Absent Radius Syndrome Congenital Amegakaryocytic Thrombocytopenia Gray Platelet Syndrome Wiskott-Aldrich Syndrome-Related Disorders Congenital Thrombotic Thrombocytopenic Purpura SECTION 3: THROMBOCYTOSIS Thrombocytosis Part VII: Infection Overview of Infection Hantavirus Pulmonary Syndrome Human Immunodeficiency Virus Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus) Parvovirus B19 Infection Bacterial Infections, Blood and Bone Marrow Features Fungal Infections, Blood and Bone Marrow Features Helminthic Infections Malaria Other Protozoan Infections Part VIII: Miscellaneous Nonneoplastic Disorders and Conditions Overview and Classification of Hemophagocytic Disorders in Bone Marrow Hematologic Manifestations of Collagen Vascular Disorders Hematologic Manifestations of Chronic Renal Disorders Lysosomal Storage Diseases With Predominantly Histiocytic Storage Other Pregnancy-Associated Hematologic Disorders Gelatinous Transformation and Other Bone Marrow Stromal Disorders Crystals in Bone Marrow Bone Abnormalities in Bone Marrow Specimens Part IX: Myeloid Neoplasms Overview and Classification of Myeloid Neoplasms Protocol for the Examination of Specimens From Patients With Hematopoietic Neoplasms Involving Bone Marrow Clinical Practice Guidelines for Initial Work-Up of Acute Leukemia SECTION 1: MYELOPROLIFERATIVE NEOPLASMS Overview of Myeloproliferative Neoplasms Chronic Myelogenous Leukemia, BCR/ABL1+ Chronic Neutrophilic Leukemia Polycythemia Vera Primary Myelofibrosis Essential Thrombocythemia Chronic Eosinophilic Leukemia, Not Otherwise Specified Systemic Mastocytosis Mast Cell Leukemia Myeloproliferative Neoplasm, Unclassifiable SECTION 2: MYELOID AND LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND ABNORMALITIES OF PDGFRA, PDGFRB, AND FGFR1 Myeloid and Lymphoid Neoplasms With PDGFRA Rearrangement Myeloid Neoplasms With PDGRFB Rearrangments Myeloid and Lymphoid Neoplasms With FGFR1 Abnormalities SECTION 3: MYELODYSPLASTIC & MYELOPROLIFERATIVE NEOPLASMS Overview of Myelodysplastic/Myeloproliferative Neoplasms Chronic Myelomonocytic Leukemia Atypical Chronic Myeloid Leukemia, BCR/ABL1- Juvenile Myelomonocytic Leukemia RARS-T Myelodysplastic/Myeloproliferative Neoplasms, Unclassifiable SECTION 4: MYELODYSPLASTIC SYNDROMES Overview and Classification of Myelodysplastic Syndromes Myelodysplasia With Single Lineage Dysplasia Myelodysplasia With Ring Sideroblasts Myelodysplasia With Multilineage Dysplasia Myelodysplasia With Increased Blasts Myelodysplastic Syndrome With Isolated del(5q) Myelodysplastic Syndrome, Unclassifiable Childhood Myelodysplastic Syndrome (Refractory Cytopenia of Childhood) SECTION 5: ACUTE MYELOID LEUKEMIA Overview of Acute Myeloid Leukemia Familial AML/MDS Acute Myeloid Leukemia With t(8;21)(q22;q22), RUNX1-RUNX1T1 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22), CBFB-MYH11 Acute Promyelocytic Leukemia With t(15;17)(q22;q21), PML-RARA Acute Promyelocytic Leukemia With Variant RARA Rearrangement Acute Myeloid Leukemia With t(9;11)(p22;q23), MLLT3-MLL Additional Genetic Subtypes of Acute Myeloid Leukemia, Including t(6;9), inv(3), t(1;22), Mutated NPM1, Mutated CEBPA Acute Myeloid Leukemia With Myelodysplasia- Related Changes Therapy-Related Myeloid Neoplasms Acute Myeloid Leukemia With Minimal Differentiation Acute Myeloid Leukemia Without Maturation Acute Myeloid Leukemia With Maturation Acute Myelomonocytic Leukemia Acute Monoblastic and Monocytic Leukemia Acute Erythroid Leukemia Acute Megakaryoblastic Leukemia Acute Basophilic Leukemia Acute Panmyelosis With Myelofibrosis Myeloid Proliferations Related to Down Syndrome Blastic Plasmacytoid Dendritic Cell Neoplasm Part X: Acute Leukemias of Ambiguous Lineage Acute Undifferentiated Leukemia Mixed Phenotype Acute Leukemia Part XI: Lymphoid Neoplasms Overview of Lymphoid Neoplasms Protocol for the Examination of Specimens from Patients With Non-Hodgkin Lymphoma/Lymphoid Neoplasms SECTION 1: B-PRECURSOR NEOPLASMS B-Lymphoblastic Leukemia Novel Genetic Subtypes of B-Lymphoblastic Leukemia SECTION 2: T-PRECURSOR NEOPLASMS T-Lymphoblastic Leukemia/Lymphoma ETP-ALL SECTION 3: MATURE B-CELL NEOPLASMS Overview and Classification of Mature Leukemias, Immunosecretory Lymphomas Monoclonal B Lymphocytes Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma B-Cell Prolymphocytic Leukemia Splenic B-Cell Marginal Zone Lymphoma Hairy Cell Leukemia Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant Lymphoplasmacytic Lymphoma Gamma Heavy Chain Disease Monoclonal Gammopathy of Undetermined Significance Plasma Cell Myeloma Burkitt Leukemia/Lymphoma Mantle Cell Lymphoma in Blood and Bone Marrow Follicular Cell Lymphoma in Blood and Bone Marrow Marginal Zone Lymphoma in Blood and Bone Marrow Large Cell Lymphoma in Blood and Bone Marrow Other B-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow SECTION 4: MATURE T/NK-CELL NEOPLASMS Overview and Classification of Mature T/NK-Cell Neoplasms T-Cell Prolymphocytic Leukemia T-Cell Large Granular Lymphocytic Leukemia Chronic Lymphoproliferative Disorder of NK Cells Aggressive NK-Cell Leukemia Adult T-Cell Leukemia Mycosis Fungoides/S　zary Syndrome Anaplastic Large Cell Lymphoma in Blood and Bone Marrow Other T-Cell Non-Hodgkin Lymphomas Involving Blood and Bone Marrow SECTION 5: HODGKIN LYMPHOMA IN BONE MARROW Hodgkin Lymphoma in Bone Marrow, Classic and Lymphocyte Predominant Subtypes Protocol for the Examination of Specimens from Patients With Hodgkin Lymphoma Part XII: Other Neoplasms Involving Bone Marrow Langerhans Cell Histiocytosis in Bone Marrow Hemophagocytic Disorders Posttransplant Lymphoproliferative Disorders in Bone Marrow Metastatic Carcinoma and Sarcoma