内容

目次

Part 1: Molecular Mechanisms of Cancer. Carcinogenesis. DNA repair and epigenetic regulation in cancer. Whole chromosome aneuploidy and cancer. Cell signaling and cancer: focus on multi drug resistance. Cancer stem cells and drug resistance. Role of stromal cells in cancer. Autophagy and apoptosis in cancer. Part 2: Nanotechnology based approaches to target cancer. Molecularly targeted therapy using small molecule drugs. Nano-carrier systems for drug delivery at sub-cellular level. Effect of nanocarrier size/surface on molecular targeting, targeting tumor microenvironment. Chemo-resistance reversal using nanomedicines. Multifunctional nano-carriers as theranostic systems for targeting cancer. Nanotechnology in clinical Immuno-diagnosis and immunotherapy. Exosomes as natural drug delivery carriers. New methods of molecular imaging. Part 3: Oligonucleotides and gene based therapies. Gene based therapeutics and vector design for efficient delivery in cancer. miRNA therapeutics. Long noncoding RNA and cancer. Cellular uptake, endocytosis and intracellular fate of RNAi. Approaches for oligonucleotides delivery of at molecular level. Bioconjugation approach for cancer targeting. Lipid based carriers for RNAi targeting cancer. Polymers for nucleic acid delivery. Inorganic nanoparticles for nucleic acid delivery. RNAi technologies reaching clinic. Part 4: IPRs, Regulatory and toxicology considerations. Intellectual property rights in development of molecular nanomedicines. Regulatory and toxicology considerations in development of nano-carriers.