Water-Insoluble Drug Formulation, 3rd ed. '18
目次
Introduction. Solubility Theories. Prediction of Solubility. Preformation Aspects of Insoluble Compounds. Water-Insoluble Drugs and Their Pharmacokinetic Behaviors. Regulatory Aspects of Dissolution for Low Solubility Drug Products. Formulation Strategies and Practice Used for Drug Candidates with Water-Insoluble Properties for Toxicology, Biology, and Pharmacology Studies in Discovery Support. Applications of Complexation in the Formulation of Insoluble Compounds. Solubilization Using CoSolvent Approach. Emulsions, Microemulsions, and Lipid-Based Drug Delivery Systems for Drug Solubilization and Delivery. Micellization and Drug Solubility Enhancement. Polymeric Micelles in Water-Insoluble Drug Delivery. Liposomes in Solubilization. Pharmaceutical Salts. Prodrugs for Improved Aqueous Solubility. Particle Size Reduction. Development of Solid Dispersions for Poorly Water-Soluble Drugs. Alternation of the Solid State of the Drug Substances: Polymorphs, Solvates, and Amorphous Forms. Pharmaceutical Powder Technology: Building the Pyramid of Knowledge and the Challenge of FDA’s PAT Initiative. Soft Gelatin Capsules Development. Oral Modified-Release Drug Delivery for Water-Insoluble Drugs. Scalable Manufacturing of Water-Insoluble Drug Products.
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