目次

1. Definition of Gastroesophageal Reflux Disease: Past, Present and Future 2. Present Diagnosis and Management of Gastroesophageal Reflux Disease: The Good, Bad and Ugly 3. Fetal and Postnatal Development of the Esophagus and Proximal Stomach 4. Histologic Definition and Diagnosis of Epithelia in the Esophagus and Proximal Stomach 5. Definition of the Normal State - A Yet Unfinished Saga 6. Definition of the Gastroesophageal Junction 7. The Normal Lower Esophageal Sphincter 8. The Pathogenesis of Early GERD 9. Correlation of LES Damage and GERD 10. The Effect of Damage to the Abdominal Segment of the LES: The Dilated Distal Esophagus 11. Columnar-Lined Esophagus (Microscopic and Visible) and Barrett Esophagus 12. Esophageal Adenocarcinoma 13. Progression of GERD at the Clinical Level 14. Progression  of GERD at a Pathological Level 15. Molecular Evolution of Esophageal Epithelial Metaplasia 16. Progression of GERD From the Perspective of LES Damage 17. New Pathologic Test of LES Damage 18. New Method of Functional Assessment of the LES 19. Prediction of Future Progression of LES Damage 20. Proof of Concept of the New Diagnostic Method 21. Application of the New Method to Present and Future Management of GERD