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PrefaceTable of Contents…Contributing Authors…Part I Introduction1. Evaluating Nanomedicines: Obstacles and AdvancementsMagdalena Swierczewska, Rachael M. Crist, and Scott E. McNeilPart II Sterility and Endotoxin Testing2. Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate TestTimothy M. Potter, Barry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia3. Considerations and Some Practical Solutions to Overcome Nanoparticle Interference with LAL Assays and to Avoid Endotoxin Contamination in NanoformulationsBarry W. Neun and Marina A. DobrovolskaiaPart III Physicochemical Characterization4. Elemental Analysis in Biological Matrices Using ICP-MSMatthew N. Hansen and Jeffrey D. Clogston5. PEG Quantitation Using Reversed Phase High Performance Liquid Chromatography and Charged Aerosol DetectionMackensie C. Smith and Jeffrey D. Clogston6. Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric AnalysisAlpana A. Dongargaonkar and Jeffrey D. Clogston7. Immunoelectron Microscopy for Visualization of NanoparticlesSarah R. Anderson, David Parmiter, Ulrich Baxa, and Kunio Nagashima 8. Imaging of Liposomes by Transmission Electron MicroscopyUlrich BaxaPart IV Immunology9. Updated Method for In Vitro Analysis of Nanoparticle Hemolytic PropertiesBarry W. Neun, Anna N. Ilinskaya, and Marina A. Dobrovolskaia10. In Vitro Assessment of Nanoparticle Effects on Blood CoagulationTimothy M. Potter, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia11. In Vitro Analysis of Nanoparticle Effects on the Zymosan Uptake by Phagocytic CellsTimothy M. Potter, Sarah L. Skoczen, Jamie C. Rodriguez, Barry W. Neun, Anna N. Ilinskaya, Edward Cedrone, and Marina A. Dobrovolskaia12. Assessing NLRP3 Inflammasome Activation by NanoparticlesBhawna Sharma, Christopher B. McLeland, Timothy M. Potter, Stephan T. Stern, and Pavan P. Adiseshaiah13. Analysis of Complement Activation by NanoparticlesBarry W. Neun, Anna A. Ilinskaya, and Marina A. Dobrovolskaia 14. Methods for Analysis of Nanoparticle Immunosuppressive Properties In Vitro and In VivoTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia15. Analysis of Pro-Inflammatory Cytokine and Type II Interferon Induction by NanoparticlesTimothy M. Potter, Barry W. Neun, Jamie C. Rodriguez, Anna N. Ilinskaya, and Marina A. Dobrovolskaia 16. Analysis of Nanoparticle Adjuvant Properties In VivoBarry W. Neun and Marina A. Dobrovolskaia17. In Vitro and In Vivo Methods for Analysis of Nanoparticle Potential to Induce Delayed Type Hypersensitivity ReactionsTimothy M. Potter, Barry W. Neun, and Marina A. Dobrovolskaia18. Autophagy Monitoring Assay II: Imaging Autophagy Induction in LLC-PK1 Cells Using GFP-LC3 Protein Fusion ConstructPavan P. Adiseshaiah, Sarah L. Skoczen, Jamie C. Rodriguez, Timothy M. Potter, Krishna Kota, and Stephan T. SternPart V Drug Release and In Vivo Efficacy19. Improved Ultrafiltration Method to Measure Drug Release from Nanomedicines Utilizing a Stable Isotope TracerSarah L. Skoczen and Stephan T. Stern20. Designing an In Vivo Efficacy Study of Nanomedicines for Preclinical Tumor Growth InhibitionPavan P. Adiseshaiah and Stephan T. Stern