目次

General introduction.- What is disease progression?- Clinical scales of disease progression and disability.- Primary progressive MS.- Epidemiology of progressive multiple sclerosis.- The neuropathology of progressive multiple sclerosis.- Mechanisms of disease progression.- Axonal injury.- Imaging disease progression.- Biomarkers of disease progression.- Symptomatic treatment for progressive multiple sclerosis.- Trials of licenced RRMS disease modifying therapies in progressive MS.- Trials of novel therapies specifically for progressive MS.- Rehabilitation.- Future therapies for progressive multiple sclerosis.