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Part 1: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES Unit I: THE CELL 1. Cellular Biology 2. Altered Cellular and Tissue Biology: Environmental Agents 3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases Unit II: GENES AND GENE-ENVIRONMENT INTERACTION 4. Genes and Genetic Diseases 5. Genes, Environment-Lifestyle, and Common Diseases 6. Epigenetics and Disease Unit III: MECHANISMS OF SELF-DEFENSE 7. Innate Immunity: Inflammation 8. Adaptive Immunity 9. Alterations in Immunity and Inflammation 10. Infection 11. Stress and Disease Unit IV. CELLULAR PROLIFERATION: CANCER 12. Cancer Biology 13. Cancer Epidemiology 14. Cancer in Children Part 2: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS Unit V: THE NEUROLOGIC SYSTEM 15. Structure and Function of the Neurologic System 16. Pain, Temperature Regulation, Sleep, and Sensory Function 17. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function 18. Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction 19. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders 20. Alterations of Neurologic Function in Children Unit VI: THE ENDOCRINE SYSTEM 21. Mechanisms of Hormonal Regulation 22. Alterations of Hormonal Regulation 23. Obesity and Disorders of Nutrition　NEW Unit VII: THE REPRODUCTIVE SYSTEMS 24. Structure and Function of the Reproductive Systems 25. Alterations of the Female Reproductive System 26. Alterations of the Male Reproductive System 27. Sexually Transmitted Infections Unit VIII: THE HEMATOLOGIC SYSTEM 28. Structure and Function of the Hematologic System 29. Alterations of Erythrocyte, Platelet, and Hemostatic Function 30. Alterations of Leukocyte and Lymphoid Function 31. Alterations of Hematologic Function in Children Unit IX: THE CARDIOVASCULAR AND LYMPHATIC SYSTEMS 32. Structure and Function of the Cardiovascular and Lymphatic Systems 33. Alterations of Cardiovascular Function 34. Alterations of Cardiovascular Function in Children Unit X: THE PULMONARY SYSTEM 35. Structure and Function of the Pulmonary System 36. Alterations of Pulmonary Function 37. Alterations of Pulmonary Function in Children Unit XI: THE RENAL AND UROLOGIC SYSTEMS 38. Structure and Function of the Renal and Urologic Systems 39. Alterations of Renal and Urinary Function 40. Alterations of Renal and Urinary Tract Function in Children Unit XII: THE DIGESTIVE SYSTEM 41. Structure and Function of the Digestive System 42. Alterations of Digestive Function 43. Alterations of Digestive Function in Children Unit XIII: THE MUSCULOSKELETAL SYSTEM 44. Structure and Function of the Musculoskeletal System 45. Alterations of Musculoskeletal Function 46. Alterations of Musculoskeletal Function in Children Unit XIV: THE INTEGUMENTARY SYSTEM 47. Structure, Function, and Disorders of the Integument 48. Alterations of the Integument in Children Unit XV: MULTIPLE INTERACTING SYSTEMS 49. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults 50. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children