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Series Preface…Preface…Table of Contents…Contributing Authors…Part I Alzheimer’s Disease as a Societal Challenge1. Worldwide Economic Costs and Societal Burden of DementiaJunfang Xu and Chengxuan Qiu2. Epidemiology and Risk Factors of Alzheimer’s Disease: A Focus on DietCécilia SamieriPart II Diagnostic Concepts3. The Dimensional Structure of Subjective Cognitive DeclineMiguel A. Fernández-Blázquez, Marina Ávila-Villanueva, and Miguel Medina4. Deriving and Testing the Validity of Cognitive-Reserve CandidatesYaakov Stern and Christian Habeck5. Methods for Pathological Classification of Alzheimer’s DiseaseJohannes Attems, Kirsty E. McAleese, and Lauren WalkerPart III Established Markers of Pathophysiology and Risk6. Cerebrospinal Fluid Biomarkers of Preclinical Alzheimer’s DiseasePanagiotis Alexopoulos and Chaido Sirinian7. Brain Structural Imaging in Alzheimer’s Disease Sven Haller, Davide Zanchi, Cristelle Rodriguez, and Panteleimon Giannakopoulos8. Brain Functional Imaging in Preclinical Alzheimer’s DiseasePeter Häussermann, Thorsten Bartsch, and Oliver Granert9. Imaging of Brain Amyloid Load in Early Alzheimer’s DiseaseTimo Grimmer and Jennifer Grace Perryman10. Functional EEG Connectivity Alterations in Alzheimer’s DiseaseFlorian Hatz and Peter FuhrPart IV Biomarker Discovery11. A Selected Reaction Monitoring Protocol for the Measurement of sTREM2 in Cerebrospinal FluidAmanda J. Heslegrave, Wendy E. Heywood, Kevin M. Mills, Henrik Zetterberg12. Soluble Amyloid Precursor Proteins in Blood: Methods and ChallengesRobert Perneczky and Panagiotis Alexopoulos13. Tau Imaging in Preclinical Alzheimer’s DiseasePaul Edison14. Retinal Imaging in Early Alzheimer’s DiseaseTom MacGillivray, Sarah McGrory, Tom Pearson, and James Cameron15. In Vivo Volumetry of the Cholinergic Basal ForebrainMichel J. Grothe, Ingo Kilimann, Lea Grinberg, Helmut Heinsen, and Stefan TeipelPart V Patient Benefit and Ethical Considerations16. Clinical Meaningfulness of Biomarkers Endpoints in Alzheimer’s Disease ResearchKok Pin Ng, Tharick A. Pascoal, Xiaofeng Li, Pedro Rosa-Neto, and Serge Gauthier17. The Ethics of Biomarker-Based Preclinical Diagnosis of Alzheimer’s DiseaseAlexander F. Kurz and Nicola T. Lautenschlager18. Shared Decision-Making and Important Medical and Social Decisions in the Context of Early Diagnosis of Alzheimer’s DiseaseKatharina Bronner and Johannes Hamann