目次

Part I　Introduction.- 1. Clinical development of genomic medicine in pulmonary diseases: Are genetic factors enough to determine the phenotype and inheritance of pulmonary diseases?.- 2. Statistical approaches and strategies for complex diseases - Overview - : What is the rationale for the genome-wide approach to understand complex diseases - its application and limitations.- Part II　Genetic Disorders in Pulmonary Disease.- 3 (旧4)Bronchial asthma: Is asthma inherited?.- 4 (旧5)COPD - Hereditary (A1-AT) and Non-hereditary: What are the roles of genetic factors in the pathogenesis of COPD?.- 5 (旧3)Smoking behavior and cessation (nicotine addiction): Are genetic factors involved in smoking behavior?.- 6. Cystic fibrosis, Primary ciliary dyskinesia and Diffuse panbronchiolitis - Hereditary and Non-Hereditary: What are the roles of genetic factors in the pathogenesis of these diseases?.- 7. Pulmonary Fibrosis -Hereditary and Nonhereditary: What are the role of genetic factors in the pathogenesis of pulmonary fibrosis? .- 8. Other diffuse lung diseases - Diffuse cystic lung diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary alveolar proteinosis, and Pulmonary alveolar microlithiasis: What are the roles of genetic factors in the pathogenesis of these diseases?.- 9. Pulmonary vascular diseases - Pulmonary hypertension and HHT: What are the roles of genetic factors in the pathogenesis of pulmonary vascular diseases?.- 10. Mycobacterial infection – TB and NTM: What are the roles of genetic factors in the pathogenesis of mycobacterial infection? .- 11. Pulmonary malignancies (1): Lung cancer: What are the roles of genetic factors in lung cancer pathogenesis?.- 12. Pulmonary malignancies (2): Mesothelioma: What are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma?.- 13. Genetic Factors in Sleep Disorders: What are the roles of genetic factors in the pathogenesis of sleep disorders?.- 14. Pharmacokinetics, pharmacodynamics, and toxicities: What should we know about genetic factors that affect the pharmacotherapy of pulmonary diseases?.- Part III　Oncogenic Driver Mutation (Somatic Mutations) in Lung Cancer.- 15. EGFR: How important is EGFR mutation status in the management of lung cancer?.- 16. ALK, and others: How important are ALK, and other mutations in the management of lung cancer?.- Part IV　Current Topics.- 17.Application of high-throughput technologies in personal genomics: How is the progress in personal genome service?.- 18. Nucleic acid amplification-based diagnostics for pulmonary diseases : What is the current state and perspectives of nucleic acid amplification technologies used in diagnostics associated with pulmonary diseases?.