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目次

Ch 1 –   Discovery and function of the HGF/MET and the MSP/RON kinase signaling pathways in cancerSilvia Benvenuti, Melissa Milan, and Paolo M. Comoglio; Candiolo Cancer Institute, Italy Ch 2 –   The role of HGF/MET and MSP/RON signaling in tumor progression and resistance to anticancer therapyLidija Klampfer; ProteXase Therapeutics, Inc., USA Benjamin Yaw Owusu; University of Alabama at Birmingham School of Medicine, USA Ch 3 – HGF Activator (HGFA) and its inhibitors HAI–1 and HAI–2: Key players in tissue repair and cancerHiroaki Kataoka and Takeshi Shimomura; University of Miyazaki, Japan Ch 4 – Physiological Functions and Role of Matriptase in CancerFausto A. Varela, Thomas E. Hyland, and Karin List; Wayne State University, USA Ch 5 – The cell–surface, transmembrane serine protease Hepsin: discovery, function and role in cancerDenis Belitškin∗, Shishir Mani Pant∗, Topi Tervonen, and Juha Klefström; University of Helsinki, Finland Ch 6 – Targeting HGF with antibodies as an anticancer therapeutic strategyDinuka M. De Silva, Arpita Roy, and Donald P. Bottaro; National Cancer Institute, USA Ch 7 – MET and RON Receptor Tyrosine Kinases as Therapeutic Antibody Targets for CancerMark Wortinger, Jonathan Tetreault, Nick Loizos, and Ling Liu; Eli Lilly, USA Ch 8 – Inhibitory antibodies of the proteases HGFA, matriptase, and hepsinDaniel Kirchhofer, Charles Eigenbrot, and Robert A. Lazarus; Genentech, USA Ch 9 – Inhibitors of the growth–factor activating proteases matriptase, hepsin and HGFA:  Strategies for rational drug design and optimizationJames W. Janetka; Washington University, USA Robert A. Galemmo, Jr.; ProteXase Therapeutics, Inc., USA Ch 10 – Cyclic peptide serine protease inhibitors based on the natural product SFTI–1Jonathan M. Harris; Queensland University of Technology, Australia Blake T. Riley, Olga Ilyichova, David E. Hoke, and Ashley M. Buckle; Monash University, Australia Ch 11 – Screening combinatorial peptide libraries in protease inhibitor drug discoveryMarcin Poreba and Paulina Kasperkiewicz; Sanford Burnham Prebys Medical Discovery Institute, USA Wioletta Rut and Marcin Drag; Wroclaw University of Technology, Poland Ch 12 –  Chemical probes targeting proteases for imaging and diagnostics in cancerPedro Gonçalves and Steven H. L. Verhelst; University of Leuven, Belgium Ch 13 – Cancer Diagnostics of protease activity and metastasisTimothy J. O’Brien and John Beard; Stage I Diagnostics, Inc., USA Ch 14 – Roles of pericellular proteases in tumor angiogenesis: therapeutic implicationsJanice M. Kraniak, Raymond R. Mattingly, and Bonnie F. Sloane; Wayne State University School, USA