目次

1. Stereological Methods to Quantify Cell Loss in the Huntington’s Disease Human Brain             Nasim F. Mehrabi, Malvindar K. Singh-Bains, Henry J. Waldvogel, and Richard L.M. Faull   2. Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells             Eleanna Stamatakou, Ye Zhu, and David C. Rubinsztein   3. A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples             Anne Steinhof, Franziska Schindler, Alexander Buntru, Sigrid Schnoegl, and Erich E. Wanker   4. Cellular Models: HD Patient-Derived Pluripotent Stem Cells             Charlene Geater, Sarah Hernandez, Leslie Thompson, and Virginia B. Mattis   5. Non-Mammalian Models of Huntington’s Disease             Anjalika Chongtham, Brett Barbaro, Tomas Filip, Adeela Syed, Weijian Huang, Marianne R. Smith, and J. Lawrence Marsh   6. Mouse Models of Huntington’s Disease             Pamela P. Farshim and Gillian P. Bates   7. Motor Assessment in Huntington’s Disease Mice             Stephen B. Dunnett and Simon P. Brooks   8. Automated Operant Assessments of Huntington’s Disease Mouse Models             Emma Yhnell and Andreas Heuer   9. Neurophysiological Assessment of Huntington’s Disease Model Mice             Elissa J. Donzis, Sandra M. Holley, Carlos Cepeda, and Michael S. Levine   10. Murine Models of Huntington’s Disease for Evaluating Therapeutics             Natalia Kosior and Blair R. Leavitt   11. Generating Excitotoxic Lesion Models of Huntington’s Disease             Mariah J. Lelos and Stephen B. Dunnett   12. Large-Brained Animal Models of Huntington’s Disease: Sheep             A. Jennifer Morton   13. Minipigs as Large-Brained Animal Model for Huntington’s Disease: From Behavior and Imaging to Gene Therapy             Ralf Reilmann and Verena Schuldenzucker   14. Non-Human Primate Models of Huntington’s Disease and Their Application in Translational Research             Romina Aron Badin   15. In Vivo Multidimensional Brain Imaging in Huntington’s Disease Animal Models             Julien Flament, Philippe Hantraye, and Julien Valette   16. Magnetic Resonance Imaging in Huntington’s Disease             Sarah Gregory, Rachael I. Scahill, Geraint Rees, and Sarah Tabrizi   17. Biofluid Biomarkers in Huntington’s Disease             Filipe B. Rodrigues, Lauren M. Byrne, and Edward J. Wild   18. Assessing and Modulating Kynurenine Pathway Dynamics in Huntington’s Disease: Focus on Kynurenine 3-Monooxygenase             Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, and Flaviano Giorgini   19. Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington’s Disease             I. Luísa Ferreira, Catarina Carmo, Luana Naia, Sandra Mota, and A. Cristina Rego   20. Using Genomic Data to Find Disease-Modifying Loci in Huntington’s Disease (HD)             Peter Holmans and Tim Stone   21. CRISPR/Cas9-Mediated Genome Editing for Huntington's Disease             Gabriel Vachey and Nicole Déglon   22. Methods for Assessing DNA Repair and Repeat Expansion in Huntington’s Disease             Thomas Massey, Branduff McAllister, and Lesley Jones   23. Translating Antisense Technology into a Treatment for Huntington’s Disease             Roger M. Lane, Anne Smith, Tiffany Baumann, Marc Gleichmann, Dan Norris, C. Frank Bennett, and Holly Kordasiewicz   24. Disease Modification through Trophic Factor Delivery             Mari Savolainen, Dwaine Emerich, and Jeffrey H. Kordower   25. Methods to Quantify Cell Signaling and GPCR Receptor Ligand Bias: Characterization of Drugs that Target the Endocannabinoid Receptors in Huntington’s Disease             Amina M. Bagher, Robert B. Laprairie, Melanie E.M. Kelly, and Eileen M. Denovan-Wright   26. Dissection and Preparation of Human Primary Fetal Ganglionic Eminence Tissue for Research and Clinical Application             Victoria H. Roberton, Anne E. Rosser, Anne-Marie McGorrian, and Sophie V. Precious   27. Robust Induction of DARPP32-Expressing GABAergic Striatal Neurons from Human Pluripotent Stem Cells             Marija Fjodorova and Meng Li   28. Quality Assessment and Production of Human Cells for Clinical Use             Lindsay Fraser, Kevin Bruce, John M. Campbell, and Paul A. De Sousa