目次

Empirical Valence Bond Simulations of Organophosphate Hydrolysis: Theory and Practice Miha Purg and Shina Caroline Lynn Kamerlin Analysis of Phosphoryl-Transfer Enzymes With QM/MM Free Energy Simulations Daniel Roston, Xiya Lu, Dong Fang, Darren Demapan and Qiang Cui Defining Dynamics of Membrane-Bound Pyrophosphatases by Experimental and Computational Single-Molecule FRET Steven P.D. Harborne, Jannik Strauss, Ainoleena Turku, Matthew A. Watson, Roman Tuma, Sarah A. Harris and Adrian Goldman A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K+ as a Cofactor Jannik Strauss, Craig Wilkinson, Keni Vidilaseris, Steven P.D. Harborne and Adrian Goldman Crystallization of Liganded Phosphatases in the HAD Superfamily Christine Harvey, Katherine O'Toole and Karen N. Allen Structure, Mechanism, and Substrate Profiles of the Trinuclear Metallophosphatases From the Amidohydrolase Superfamily Swapnil V. Ghodge and Frank M. Raushel Affinities and Comparisons of Enzyme States by Principal Component Analysis of NMR Spectra, Automated Using TREND Software Jia Xu and Steven R. Van Doren Assessment and Impacts of Phosphorylation on Protein Flexibility of the ?-D-Phosphohexomutases Kyle M. Stiers and Lesa J. Beamer Chemical Tools for Studying the Impact of cis/trans Prolyl Isomerization on Signaling: A Case Study on RNA Polymerase II Phosphatase Activity and Specificity Nathaniel Tate Burkholder, Brenda Medellin, Seema Irani, Wendy Matthews, Scott A. Showalter and Yan Jessie Zhang Quantitative Analysis of Intracellular Response Regulator Phosphatase Activity of Histidine Kinases Rong Gao and Ann M. Stock Measuring the Activities of Two-Component Regulatory System Phosphatases Robert B. Bourret and Ruth E. Silversmith Assembly of PGAM5 Into Multimeric Complexes Provides a Mechanism for Allosteric Regulation of Phosphatase Activity Peter Tipton, Tong Su and Mark Hannink Purification of Lipin and Measurement of Phosphatidic Acid Phosphatase Activity From Liposomes Mitchell E. Granade and Thurl E. Harris Combining SAMDI Mass Spectrometry and Peptide Arrays to Profile Phosphatase Activities Lindsey C. Szymczak, Che-Fan Huang, Eric J. Berns and Milan Mrksich Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation Daniel R. Dempsey and Philip A. Cole