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Antimicrobial Resistance in the 21st Century 2nd ed.(Emerging Infectious Diseases of the 21st Century) H XIV, 436 p. 18

Fong, I. W., Shlaes, David, Drlica, Karl 　編

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発行年月	2018年11月
出版社／提供元	Springer International Publishing
出版国	スイス
言語	英語
媒体	冊子
装丁	hardcover
ページ数／巻数	XVIII, 775 p. 106 illus., 74 illus. in color.
ジャンル	洋書／生命科学・医学／社会医学／小児・母子衛生学
ISBN	9783319785370
商品コード	1027174450
本の性格	学術書
新刊案内掲載月	2018年06月
商品URL	https://kw.maruzen.co.jp/ims/itemDetail.html?itmCd=1027174450

内容

Antimicrobial resistance can develop in any type of microbe (germ). Microbes can develop resistance to specific medicines. A common misconception is that a person’s body becomes resistant to specific drugs. However, it is microbes, not people that become resistant to the drugs. Drug resistance happens when microbes develop ways to survive the use of medicines meant to kill or weaken them. If a microbe is resistant to many drugs, treating the infections it causes can become difficult or even impossible. Someone with an infection that is resistant to a certain medicine can pass that resistant infection to another person. In this way, a hard-to-treat illness can be spread from person to person. In some cases, the illness can lead to serious disability or even death. This comprehensive, up-to-date volume aims to define issues and potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria (Streptococcus pneumoniae, enteroccoci, staphylococci, gram-negative bacilli, mycobacteria species) viruses (HIV, herpesviruses), and fungi (Candida species, fusarium etc.). The chapters will explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions. This volume will also describe the steps that researchers are taking to develop molecular methods for detecting resistance; develop drugs and other means to deal with newly-resistant organisms. A special chapter to address the issues on strategies to limit antimicrobial resistance propagation will be included in this volume.

Chapter1: Introduction : Coordinated Global Action is Needed to Combat Antimicrobial Resistance.- Part I: Examples of Resistance.- Chapter2: Antimicrobial Resistance Among Streptococcus pneumoniae.- Chapter3: Emergence of MRSA in the Community.- Chapter4: Resistance of Gram-negative Bacilli to Antimicrobials.- Chapter5: Drug Resistance in Tuberculosis.- Chapter6: Anaerobic Bacteria: Antimicrobial Susceptibility Testing and Resistance Patterns.- Chapter7: Clinical Significance and Biologic Basis of HIV Drug Resistance.- Chapter8: Resistance of Herpesviruses to Antiviral Agents.- Chapter9: Heteroresistance: A Harbinger of Future Resistance.- Part II: Biology of Resistance.- Chapter10: Epidemiology of Bacterial Resistance.- Chapter11: Transmissible Antibiotic Resistance.- Chapter12: Antibiotics and Resistance in the Environment.- Chapter13: Phenotypic Tolerance and Bacterial Persistence.- Chapter14: Staphylococcus aureus Adaptation During Infection.- Chapter15: Bacterial Signal Transduction Systems in Antimicrobial Resistance.- Chapter16: Fluoroquinolone Interactions with Bacterial Type II Topoisomerases and Target-mediated Drug Resistance.- Part III: Finding New Antimicrobials.- Chapter17: Natural Products in Antibiotic Discovery.- Chapter18: The New vs. Old Target Debate For Drug Discovery.- Chapter19: Non-quinolone Topoisomerase Inhibitors.- Chapter20: Antimicrobial-Mediated Bacterial Suicide.- Chapter21: PK/PD-based Prediction of “Anti-mutant” Antibiotic Exposures Using In Vitro Dynamic Models.- Part IV: Bringing Compounds to Market.- Chapter22: The Role of Pharmacometrics in the Development of Antimicrobial Agents.- Chapter23: New Regulatory Pathways for Antibacterial Drugs.- Chapter24: Economic Incentives for Antibacterial Drug Development: Alternative Market Structures to Promote Innovation.

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