目次

Preface Contributors Part 1 – Introduction 1.      Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis Benedetto Daniele Giaimo and Tilman Borggrefe Part 2 – Molecular mechanisms of receptor/ligand interactions 2.      Structural insights into Notch receptor-ligand interactions Penny Handford, Boguslawa Korona, Richard Suckling, Christina Redfield and Susan Lea 3.      The Molecular Mechanism of Notch Activation Klaus N. Lovendahl, Stephen C. Blacklow and Wendy R. Gordon 4.      Regulation of Notch Function by O-Glycosylation Beth M. Harvey and Robert S. Haltiwanger 5.      Modeling the Notch response Udi Binshtok and David Sprinzak 6.      Endocytic trafficking of the Notch receptor Björn Schnute, Tobias Troost and Thomas Klein Part 3 – Intracellular signaling mechanisms 7.      The Notch Interactome: complexity in signaling circuitry Diana M. Ho, K. G. Guruharsha and Spyros Artavanis-Tsakonas 8.      Integration of Drosophila and Human Genetics to understand Notch signaling related diseases Shinya Yamamoto and Jose L. Salazar 9.      Mechanisms of non-canonical signaling in health and disease: Diversity to take therapy up a Notch? Victor Alfred and Thomas Vaccari 10.  The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms Diana Bellavia, Saula Checquolo, Rocco Palermo and Isabella Screpanti 11.  Notch and neurogenesis Anna Engler, Runrui Zhang and Verdon Taylor 12.  Notch and stem cells Anna Bigas and Cristina Porcheri 13.  Oscillatory control of Notch signaling in development Ryoichiro Kageyama, Hiromi Shimojo and Akihiro Isomura 14.  CSL-associated corepressor and coactivator complexes Franz Oswald and Rhett A. Kovall Part 4 – Disease links and therapeutics 15.  Notch and senescence Matthew Hoare and Masashi Narita 16.  Control of blood vessel formation by Notch signaling Fabian Tetzlaff and Andreas Fischer 17.  Notch and T cell function – a complex tale Jyothi Vijayaraghavan and Barbara A. Osborne 18.  Notch in leukemia Anna C. Gormley, Qing Wang and Mark Chiangs