目次

Section I: History, Chemistry Metabolism, Circulation and Regulation 1. Historical Overview of Vitamin D; 2. Evolutionary Biology of vitamin D; 3. Photobiology of Vitamin D; 4. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases); 5. CYP24A1: Structure, Function, and Physiological Role; 6. Alternative Pathways for Vitamin D Metabolism; 7. The Vitamin D-Binding Protein; 8. Regulation of Renal and Extrarenal 1a-Hydroxylase Section II: Mechanism of Action 9. Genome-Wide Perspectives on Vitamin D Receptor-Mediated Control of Gene Expression in Target Cells; 10. Diverse Mechanisms of Transcriptional Regulation by the Vitamin D Receptor; 11. Structural Basis for Ligand Activity in Vitamin D Receptor; 12. Ligand-Independent Actions of Vitamin D Receptor; 13. Vitamin D and Chromatin; 14. Vitamin D, nutrition and epigenetics; 15. Vitamin D and MicroRNAs; 16. OMICS analyses and vitamin D - Pathway analysis and Bioinformatics Section III: Mineral and Bone Homeostasis 17. Vitamin D Regulation of Osteoblast Function; 18. Osteoclastogenesis and Vitamin D; 19. Vitamin D Activities in Osteocytes; 20. Regulation of Intestinal Calcium and Phosphate Absorption; 21. Cartilage; 22. Vitamin D and Bone: An Integrated Approach; 23. Vitamin D in Dentoalveolar and Oral Health Section IV: Extra-Skeletal Targets 24. Vitamin D and the Kidney; 25. Vitamin D, the calcium-sensing receptor and the parathyroids; 26. Vitamin D and FGF23; 27. The Role of Vitamin D and Its Receptor in Hair Follicle Biology; 28. Vitamin D, Calcium, and the Epidermis; 29. Vitamin D and the Cardiovascular System; 30. Vitamin D Brain Development and Function; 31. Vitamin D, Vitamin D Receptor, and Adipose Tissue: Focus on Cellular Mechanisms; 32. Vitamin D and Skeletal Muscle; 33. Understanding Vitamin D from Mouse Knockout Models Section V: Human Physiology 34. Pharmacology and Pharmacokinetics; 35. Fetus, Neonate, lactation and Infant; 36. Vitamin D and the Placenta; 37. Consequences of Perinatal Vitamin D Deficiency on Later Bone Health; 38. Adolescence and Acquisition of Peak Bone Mass; 39. The Role of Vitamin D in Orthopedic Surgery; 40. Vitamin D and Muscle Performance in Athletes and with Ageing; 41. Role in Reproductive Biology and Reproductive Dysfunction in Women; 42. Vitamin D, Reproductive Biology, and Dysfunction in Men; 43. Vitamin D and the Renin-Angiotensin System; 44. Vitamin D: Presence and Function in the Eye; 45. Adult Vitamin D Deficiency and Adverse Brain Outcomes; 46. Vitamin D and the lungs Section VI: Diagnosis and Management 47. Defining thresholds for vitamin D (different perspectives); 48. Mass Spectrometry Assays of Vitamin D Metabolites; 49. Free Vitamin D: Concepts, Assays, Outcomes, and Prospects; 50. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems, and Interpretation; 51. Detection of 1,25-Dihydroxyvitamin D in Human Serum; 52. Bone Histomorphometry; 53. Radiology of Rickets and Osteomalacia; 54. High-Resolution Imaging Techniques for Bone Quality Assessment; 55. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets