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目次

Foreword Preface GENERAL PRINCIPLES 1. Historical Backgroundand Overview A. Varki and N. Sharon 2. Structural Basis of GlycanDiversity C.R. Bertozzi and D. Rabuka 3. Cellular Organization ofGlycosylation A. Varki, J.D. Esko, and K.J. Colley 4. GlycosylationPrecursors H.H. Freeze and A.D. Elbein 5. Glycosyltransferases andGlycan-processing Enzymes J.M. Rini, J.D. Esko, and A. Varki 6.Biological Roles of Glycans A. Varki and J.B. Lowe 7. A Genomic View ofGlycobiology B. Henrissat, A. Surolia, and P. Stanley STRUCTURE ANDBIOSYNTHESIS 8. N-Glycans P. Stanley, H. Schachter, and N. Taniguchi9. O-GalNAc Glycans I. Brockhausen, H. Schachter, and P. Stanley 10.Glycosphingolipids R.L. Schnaar, A. Suzuki, and P. Stanley 11.Glycosylphosphatidylinositol Anchors M.A.J. Ferguson, T. Kinoshita, andG.W. Hart 12. Other Classes of ER/Golgi-derived Glycans H.H. Freeze andR.S. Haltiwanger 13. Structures Common to Different Glycans P. Stanleyand R.D. Cummings 14. Sialic Acids A. Varki and R. Schauer 15.Hyaluronan V. Hascall and J.D. Esko 16. Proteoglycans and SulfatedGlycosaminoglycans J.D. Esko, K. Kimata, and U. Lindahl 17.Nucleocytoplasmic Glycosylation G.W. Hart and C.M.West 18. The O-GlcNAcModification G.W. Hart and Y. Akimoto ORGANISMAL DIVERSITY 19.Evolution of Glycan Diversity A. Varki, H.H. Freeze, and P. Gagneux 20.Eubacteria and Archaea J.D. Esko, T.L. Doering, and C.R.H. Raetz 21.Fungi R.D. Cummings and T.L. Doering 22. Viridiplantae M.E. Etzlerand D. Mohnen 23. Nematoda R.D. Cummings and J.D. Esko 24.Arthropoda M. Tiemeyer, S.B. Selleck, and J.D. Esko 25. DeuterostomesH.H. Freeze, V.D. Vacquier, and J.D. Esko GLYCAN-BINDING PROTEINS26. Discovery and Classification of Glycan-binding Proteins A. Varki, M.E.Etzler, R.D. Cummings, and J.D. Esko 27. Principles of Glycan RecognitionR.D. Cummings and J.D. Esko 28. R-type Lectins R.D. Cummings and M.E.Etzler 29. L-type Lectins M.E. Etzler, A. Surolia, and R.D. Cummings30. P-type Lectins A. Varki and S. Kornfeld 31. C-type Lectins R.D.Cummings and R.P. McEver 32. I-type Lectins A. Varki and P.R. Crocker33. Galectins R.D. Cummings and F.-T. Liu 34. Microbial Lectins:Hemagglutinins, Adhesins, and Toxins J.D. Esko and N. Sharon 35.Proteins that Bind Sulfated Glycosaminoglycans J.D. Esko and R.J. LinhardtGLYCANS IN PHYSIOLOGY AND DISEASE 36. Glycans in Glycoprotein QualityControl H.H. Freeze, J.D. Esko, and A.J. Parodi 37. Free Glycans asSignaling Molecules M.E. Etzler and J.D. Esko 38. Glycans inDevelopment and Systemic Physiology A. Varki, H.H. Freeze, and V.D.Vacquier 39. Bacterial and Viral Infections V. Nizet and J.D. Esko40. Parasitic Infections R.D. Cummings and S. Turco 41. GeneticDisorders of Glycan Degradation H.H. Freeze 42. Genetic Disorders ofGlycosylation H.H. Freeze and H. Schachter 43. Glycans in AcquiredHuman Diseases A. Varki and H.H. Freeze 44. Glycosylation Changes inCancer A. Varki, R. Kannagi, and B.P. Toole METHODS AND APPLICATIONS45. Antibodies and Lectins in Glycan Analysis R.D. Cummings and M.E.Etzler 46. Glycosylation Mutants of Cultured Cells J.D. Esko and P.Stanley 47. Structural Analysis of Glycans B. Mulloy, G.W. Hart, and P.Stanley 48. Glycomics C.R. Bertozzi and R. Sasisekharan 49. Chemicaland Enzymatic Synthesis of Glycans and Glycoconjugates P.H. Seeberger, N.Finney, D. Rabuka, and C.R. Bertozzi 50. Chemical Tools for InhibitingGlycosylation J.D. Esko and C.R. Bertozzi 51. Glycans in Biotechnologyand the Pharmaceutical Industry C.R. Bertozzi, H.H. Freeze, A. Varki, andJ.D. Esko Glossary Study Guide Index