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Section I: Introduction to Virology 1. Introduction to Virology 2 Nicholas H. Acheson 2. Virus Structure and Assembly 18 Stephen C. Harrison 3. Virus Classification: The World of Viruses 31 Nicholas H. Acheson 4. Virus Entry 45 Ari Helenius Section II: Viruses of Bacteria and Archaea 5. Single–Stranded RNA Bacteriophages 59 Jan van Duin 6. Microviruses 69 Bentley Fane 7. Bacteriophage T7 77 William C. Summers 8. Bacteriophage Lambda 85 Michael Feiss 9. Viruses of Archaea 97 David Prangishvili Section III: Positive–Strand RNA Viruses of Eukaryotes 10. Cucumber Mosaic Virus 112 Ping Xu, Marilyn J. Roosinck 11. Picornaviruses 125 Bert L. Semler 12. Flaviviruses 137 Richard Kuhn 13. Togaviruses 148 Milton Schlesinger, Sondra Schlesinger, Richard Kuhn 14. Coronaviruses 159 Mark Denison, Michelle M. Becker Section IV: Negative–Strand and Double–Stranded RNA Viruses of Eukaryotes 15. Paramyxoviruses and Rhabdoviruses 175 Nicholas H. Acheson, Daniel Kolakofsky, Christopher Richardson, Laurent Roux 16. Filovirouses 188 Heinz Feldman, Hans–Dieter Klenk, Nicholas H. Acheson 17. Bunyaviruses 200 Richard M. Elliott 18. Influenza Viruses 225 Terence S. Dermody, James D. Chappell 19. Reoviruses 225 Terence S. Dermody, James D. Chappell Section V: Small DNA Viruses of Eukaryotes 20. Parvoviruses 238 Peter Beard 21. Polyomaviruses 247 Nicholas H. Acheson 22. Papillomaviruses 263 Greg Matlashewski, Lawrence Banks Section VI: Larger DNA Viruses of Eukaryotes 23. Adenoviruses 274 Philip Branton 24. Herpesviruses 285 Bernard Roisman, Gabriella Campadelli–Fiume, Richard Longnecker 25. Baculoviruses 302 Eric B. Carstens 26. Poxviruses 312 Richard C. Condit 27. Viruses of Algae and Mimivirus 325 Michael J. Allen, William H. Wilson Section VII: Viruses That Use A Reverse Transcriptase 28. Retroviruses 342 Alan Cochrane 29. Human Immunodeficiency Virus Alan Cochrane 30. Hepadnaviruses 365 Christopher Richardson Section VIII: Viroids and Prions 31. Viroids and Hepatitis Delta Virus 378 Jean–Pierre Perreault, Martin Pelchat 32. Prions 387 Dalius J. Briedis Section IX: Host Defenses Against Virus Infection 33. Intrinsic Cellular Defenses Against Virus Infection 398 Karen Mossman, Pierre Geninm, John Hiscott 34. Innate and Adaptive Immune Responses to Virus Infection 415 Malcolm G. Baines, Karen Mossman Section X: Antiviral Agents and Virus Vectors 35. Antiviral Vaccines 428 Brian Ward 36. Antiviral Chemotherapy Donald M. Coen 37. Eukaryotic Virus Vectors 456 GLOSSARY 471 CREDITS 484 NAME INDEX 489 SUBJECT INDEX 491 Rénald Gilbert, Bernard Massie