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PART I: PATHOLOGICAL SUBSTRATES AND MECHANISMS OF EPILEPTOGENESIS Section A – Epidemiology and Natural History of Epilepsy 1. Epidemiologic Aspects of Epilepsy 2. The Natural History of Seizures 3. Experimental Models of Seizures and Mechanisms of Status Epileptics and Epileptogenesis 4. Genetics of the Epilepsies 5. Pictoral Atlas of Epilepsy Substrates PART II: BASIC PRINCIPLES OF ELECTROENCEPHALOGRAPHY 6. Neurophysiologic Basis of the Electroencephalogram 7. Localization and Field Determination in Electroencephalography 8. Electroencephalographic Atlas of Epileptiform Abnormalities PART III: EPILEPTIC SEIZURES AND SYNDROMES Section A Epileptic Seizures 9. Terminology for Seizures and the Epilepsies 10. Epileptic Auras 11. Focal Motor Seizures 12. Focal Seizures with Impaired Consciousness 13. Autonomic Seizures, Autonomic Effects of Seizures, and SUDEP 14. Generalized Motor Seizures 15. Absence Seizures 16. Epileptic Spasms Section B Epilepsy Conditions: Diagnosis and Treatment 17. Presumed Genetic and Benign Focal Epilepsies of Childhood 18. Idiopathic Generalized Epilepsy Syndromes of Childhood and Adolescence 19. Progressive and Infantile Myoclonic Epilepsies 20. Encephalopathic Generalized Epilepsy and Lennox-Gastaut Syndrome 21. Continuous Spike-and-Wave During Sleep Including Landau-Kleffner Syndrome 22. Epilepsy with Reflex Seizures 23. Rasmussen Syndrome 24. Temporal Lobe Epilepsies 25. The Extratemporal Epilepsies 26. Malformations of Cortical Development and Epilepsy 27. Brain Tumors and Epilepsy 28. Post-Traumatic Epilepsy 29. Epilepsy in the Setting of Cerebrovascular Disease 30. Epilepsy in the Setting of Neurocutaneous Syndromes 31. Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders 32. Central Nervous System Infections and Epilepsy 33. Autoimmune Issues in Epilepsy Section C Diagnosis and Treatment of Seizures in Special Clinical Settings 34. Febrile Seizures 35. Neonatal Seizures 36. Seizures Associated with Nonneurologic Medical Conditions 37. Sleep and Epilepsy 38. Status Epilepticus 39. Application of Electroencephalography in the Intensive Care Setting Section D Differential Diagnosis of Epilepsy 40. Psychogenic Nonepileptic Seizures 41. Other Nonepileptic Paroxysmal Disorders PART IV: ANTIEPILEPTIC MEDICATIONS Section A General Principles of Antiepileptic Drug Therapy 42. Antiepileptic Drug Development and Experimental Models 43. Mechanisms of Action of Antiepileptic Drugs 44. Pharmacokinetics and Drug Interactions 45. Initiation and Discontinuation of Antiepileptic Drugs 46. Hormones, Catamenial Epilepsy, Sexual Function, and Reproductive and Bone Health in Epilepsy 47. Treatment of Epilepsy During Pregnancy 48. Individual Approach to Laboratory Monitoring of Antiepileptic Drugs 49. Genetic Influences on Responses to Drugs Used to Treat Epilepsy Section B Specific Antiepileptic Medications and Other Therapies 50. Benzodiazepines 51. Carbamazepine, Oxcarbazepine, and Eslicarbazepine 52. Ethosuximide 53. Ezogabine (Retigabine) 54. Felbamate 55. Gabapentin and Pregabalin 56. Lacosamide 57. Lamotrigine 58. Levetiracetam 59. Perampanel 60. Phenobarbital and Primidone 61. Phenytoin and Fosphenytoin 62. Rufinamide 63. Topiramate 64. Valproate 65. Vigabatrin 66. Zonisamide 67. Adrenocorticotropin and Steroids 68. Antiepileptic Drugs in Clinical Development 69. Less Commonly Used Antiepileptic Drugs 70. Dietary Therapies for Epilepsy 71. Vagus Nerve Stimulation Therapy PART V: EPILEPSY SURGERY Section A Identifying Surgical Candidates, Defining the Epileptogenic Zone, and Mapping Eloquent Cortex 72. Issues of Medical Intractability for Surgical Candidacy 73. Magnetic Resonance Imaging in Evaluation for Epilepsy Surgery 74. Video EEG Monitoring in the Presurgical Evaluation 75. Nuclear Imaging (PET, SPECT) 76. Magnetoencephalography 77. MRI Post-Processing Techniques and Clinical Applications 78. Diffusion Tensor Imaging (DTI) and EEG-Correlated fMRI 79. Language and Memory Mapping 80. Mapping Motor Function 81. Strategies and Indications for Evaluation with Invasive Electrodes Section B Epilepsy Surgery in Different Clinical Settings 82. Surgery for Medically Refractory Temporal Lobe Epilepsy 83. Surgery for Focal Cortical Dysplasias 84. Hemispherectomy: Indications, Procedures, and Outcome 85. Surgical Approach in Multilesional or Multilobar Epilepsies 86. Surgical Approach in Non-lesional Cases 87. Hypothalamic Hamartoma 88. Corpus Callosotomy and Multiple Subpial Transection 89. Special Considerations in Children 90. Outcome and Complications of Epilepsy Surgery 91. Electrical Stimulation for the Treatment of Epilepsy PART VI: PSYCHOSOCIAL IMPACT, QUALITY OF CARE, COMORBIDITIES, AND ECONOMICS OF EPILEPSY 92. Cognitive Effects of Epilepsy and its Treatments 93. Psychiatric Comorbidity of Epilepsy 94. Driving and Social Issues in Epilepsy 95. Quality of Life with Epilepsy Final Note: A Mother’s Perspective Appendix Indications for Antiepileptic Drugs Sanctioned by the United States Food and Drug Administration Index