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【高島明彦（学習院大学）他編・タウの生物学】

Tau Biology (Advances in Experimental Medicine and Biology, Vol. 1184) '20

Takashima, Akihiko, Wolozin, Benjamin, Buee, Luc 　編

在庫状況海外在庫有り	お届け予定日 1ヶ月	数量冊
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発行年月	2020年02月
出版社／提供元	Springer Singapore
出版国	シンガポール
言語	英語
媒体	冊子
装丁	hardcover
ページ数／巻数	XI, 416 p. 83 illus., 75 illus. in color.
ジャンル	洋書／生命科学・医学／神経・精神科学／神経科学
ISBN	9789813293571
商品コード	1030622478
本の性格	学術書
新刊案内掲載月	2020年02月
商品URL	https://kw.maruzen.co.jp/ims/itemDetail.html?itmCd=1030622478

内容

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

1) Structure and role of Tau molecule.- (1) Tau structure in solution: FRET study.- (2) Tau structure in solution: NMR study.- (3) Structure of NFT: Biochemical approach.- (4) Structure of NFT: CryoEM approach.- (5) MAPT tau gene and FTDP-17 mutation.- (6) Tau phosphorylation.- (7) Tau acetylation.- (8) Tau truncation.- (9) Tau interacted proteins: interactome.- (10) Tau clearance mechanism.- 2) Tau localization and function.- (11) Localization of Tau.- (12) Axonal transport.- (13) Synaptic localization of tau.- (14) Role of tau in synapse.- (15) Tau in nucleus and nucleic acids.- (16) Tau and the translational stress response.- 3) Tauopathies; pathology, drivers, and marker.- (17) Tau pathology with aging.- (18) Clinical symptom and pathology of FTD including FTDP-17.- (19) Chronic Traumatic Encephalopathy.- (20) Myotonic dystrophies.- (21) Tau PET.- (22) Tau PET/connectome/fMRI.- (23) Stress.- (24) Diabetes.- (25) Relationship between ApoE and tau.- (26) Relationship between Ab and tau.- 4) Tau aggregation, and therapy.- (27) Tau Oligomer.- (28) Tau droplet formation.- (29) Stress granule.- (30) Tau secretion.- (31) Tau seeding.- (32) Prion-like Tau propagation.- (33) Experimental models for tauopathies.- (34) Dementia therapy targeting tau.- (35) Tau aggregation inhibitor.

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