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PREFACE xi ABOUT THE AUTHORS xiii CONTRIBUTORS xv PART I INTRODUCTION AND BASICS OF ADVANCED DRUG DELIVERY 1 1 Physiological Barriers in Advanced Drug Delivery: Gastrointestinal Barrier 3 D. Alexander Oh and Chi H. Lee 2 Solubility and Stability Aspects in Advanced Drug Delivery 21 Hoo–Kyun Choi, Robhash K. Subedi, and Chi H. Lee 3 The Role of Transporters and the Efflux System in Drug Delivery 47 Varun Khurana, Dhananjay Pal, Mukul Minocha, and Ashim K. Mitra 4 Biomaterial in Advanced Drug Delivery 75 Megha Barot, Mitesh Patel, Xiaoyan Yang, Wuchen Wang, and Chi H. Lee PART II STRATEGIES FOR ADVANCED DRUG DELIVERY 103 5 Strategies of Drug Targeting 105 Ravi S. Shukla, Zhijin Chen, and Kun Cheng 6 Prodrug and Bioconjugation 123 Ramya Krishna Vadlapatla, Sujay Shah, Aswani Dutt Vadlapudi, and Ashim K. Mitra 7 Nanoscale Drug Delivery Systems 141 Mitan R. Gokulgandhi, Ashaben Patel, Kishore Cholkar, Megha Barot, and Ashim K. Mitra 8 Stimuli–Responsive Target Strategies 157 Chi H. Lee 9 Implants 183 Aswani Dutt Vadlapudi, Ashaben Patel, Ramya Krishna Vadlapatla, Durga Paturi, and Ashim K. Mitra 10 Aptamers in Advanced Drug Delivery 201 Weiwei Gao, Omid C. Farokhzad, and Nazila Kamaly 11 Nanofiber 219 Megha Barot, Mitan R. Gokulgandhi, Animikh Ray, and Ashim K. Mitra 12 Biomimetic Self–Assembling Nanoparticles 231 Maxim G. Ryadnov 13 Protein and Peptide Drug Delivery 241 Mitesh Patel, Megha Barot, Jwala Renukuntla, and Ashim K. Mitra 14 Delivery of Nucleic Acids 257 Shaoying Wang, Bin Qin, and Kun Cheng 15 Delivery of Vaccines 275 Hari R. Desu, Rubi Mahato, and Laura A. Thoma PART III TRANSLATIONAL RESEARCH OF ADVANCED DRUG DELIVERY 297 16 Regulatory Considerations and Clinical Issues in Advanced Drug Delivery 299 Mei–Ling Chen 17 Advanced Drug Delivery in Cancer Therapy 323 Wanyi Tai and Kun Cheng 18 Advanced Delivery in Cardiovascular Diseases 341 Gayathri Acharya, Wuchen Wang, Divya Teja Vavilala, Mridul Mukherji, and Chi H. Lee 19 Recent Advances in Ocular Drug Delivery 365 Varun Khurana, Deep Kwatra, Vibhuti Agrahari, and Ashim K. Mitra 20 Advanced Drug Delivery Against STD 381 Chi H. Lee 21 Advanced Drug Delivery to the Brain 405 Nanda K. Mandava, Mitesh Patel, and Ashim K. Mitra PART IV FUTURE APPLICATIONS OF ADVANCED DRUG DELIVERY IN EMERGING RESEARCH AREAS 423 22 Cell–Based Therapeutics 425 Zhaoyang Ye, Yan Zhou, Haibo Cai, and Wen–Song Tan 23 Biomedical Applications and Tissue Engineering of Collagen 445 Chi H. Lee and Yugyung Lee 24 Molecular Imaging of Drug Delivery 469 Zheng–Rong Lu ANSWERS 489 INDEX 511