Alzheimer’s Disease:Methods and Protocols (Methods in Molecular Biology, Vol. 2561) '22
目次
Preface…Table of Contents…Contributing Authors…Part I Human Brain Preparations1. Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain TissueCaitlin S. Latimer, Erica J. Melief, Jeanelle Ariza-Torres, Kim Howard, Amanda R. Keen, Lisa M. Keene, Aimee M. Schantz, Trevor M. Sytsma, Angela M. Wilson, Thomas J. Grabowski, Martin Darvas, Kristen Dams O’Connor, Amber L. Nolan, Brian L. Edlow, Christine L. Mac Donald, and C. Dirk Keene2. Extraction and Purification of Single Nuclei from Frozen Human Brain TissueCarter R. Palmer and Jerold Chun3. Isolation of Human Microglia from Neuropathologically Diagnosed Cases in the Single-Cell EraLih-Fen Lue, Douglas G. Walker, Suet Theng Beh, and Thomas G. Beach4. Microglia in Human Postmortem Brain Samples: Quantitative Ultrastructural Analysis of Scanning Electron Microscopy ImagesMarie-Kim St-Pierre, Eva Šimončičová, Micaël Carrier, and Marie-Ève Tremblay5. Three-Dimensional Imaging of Fibrinogen and Neurovascular Alterations in Alzheimer’s DiseaseMaria Merlini, Elif G. Sozmen, Keshav S. Subramanian, Alissa L. Nana, William W. Seeley, and Katerina AkassoglouPart II Human Neural Cellular Models6. Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer’s DiseaseJessica E. Young and Lawrence S.B. Goldstein7. Modeling Alzheimer’s Disease using Human Brain OrganoidsKarina Karmirian, Mariana Holubiec, Livia Goto-Silva, Iván Fernández Bessone, Gabriela Vitória, Beatriz Mello, Matias Alloatti, Bart Vanderborght, Tomás L. Falzone, and Stevens Rehen8. 3D Biohybrid StarPEG-Heparin Hydrogel Cultures for Modeling Human Neuronal Development and Alzheimer’s Disease PathologyTohid Siddiqui, Hilal Celikkaya, Zeynep Tansu Atasavum, Stanislava Popova, Uwe Freudenberg, Carsten Werner, and Caghan KizilPart III Nucleic Acid Analyses of Human Brain9. Computational Approaches to Assess Abnormal Metabolism in Alzheimer’s Disease Using TranscriptomicsHatice Büşra Lüleci, Dilara Uzuner, Tunahan Çakır, and Madhav Thambisetty10. FISHing for Chromosome Instability and Aneuploidy in the Alzheimer’s Disease BrainYuri B. Yurov, Svetlana G. Vorsanova, and Ivan Y. Iourov11. Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Post-Mortem Human BrainDiego Perez-Rodriguez, Maria Kalyva, Catherine Santucci, and Christos ProukakisPart IV Lipids Analyses of Human Brain12. Mass Spectrometry Analysis of the Human Brain SphingolipidomeXin Ying Chua, Ryan Huang, Deron Herr, Mitchell K.P. Lai, Markus R. Wenk, and Federico Torta13. Mass Spectrometry for the Advancement of Lipid Analysis in Alzheimer’s ResearchJonatan Martínez-Gardeazabal, Marta Moreno-Rodríguez, Estíbaliz González de San Román, Beatriz Abad, Iván Manuel, and Rafael Rodríguez-PuertasPart V Protein Analyses of Human Brain14. The Use of Affinity Purification-Mass Spectrometry to identify Phosphorylates Tau Interactors in Alzheimer’s DiseaseGeoffrey Pires, Beatrix Ueberheide, Thomas Wisniewski, and Eleanor Drummond15. In Vitro Amplification of Pathogenic Tau Seeds from Neurodegenerative Disease Patient BrainsHong Xu and Virginia M.-Y. Lee16. Aβ and Tau Prions Causing Alzheimer’s DiseaseCarlo Condello, Gregory E. Merz, Atsushi Aoyagi, William F. DeGrado, and Stanley B. PrusinerSubject Index List…
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