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Preface. Plenary lectures. Regulation of mast cell differentiation(Y. Kitamura et al.). The histamine H3 receptor: gene organization, mutipleisoforms, constitutive activity and molecular pharmacology (J.-M. Arrang etal.). CNS overviews. The discovery of potent non-imidazole H3-receptorhistamine antagonists (C.R. Ganellin et al.). Histaminergic and cholinergictransmission in cognitive processes (A. Philipu, H. Prast, M.M. Kraus).Physiology and pharmacology of histaminergic neurons (H.L. Haas et al.).Histaminergic modulation of basal forebrain cholinergic neurons (M.B. Passaniet al.). The interaction between the histaminergic system and the NO-cGMPpathway: A functional neuroanatomical study in the mammillary region andcerebral cortex of the rat (H.W.M. Steinbusch et al.). The Histamine H3receptor and its ligands: from gene to clininc. Molecular identification ofthe human and rat histamine H3- receptors: New pharmacological and functionalinsight (T.W. Lovenberg et al.). Clonining functional characterisation andCNS expression of H3 receptor isoforms (R. Leurs et al.). Partial agonistsfor the histamine H3 receptor with high in vivo activity (W. Schunack etal.). Structure-activity relationship of histamine H3-ligands: Organicsynthesis imidazole C-nucleoside derivatives (S. Harusawa et al.). HistamineH1 antagonists. Role of protein kinase C-a in signalling from the histamineH1-receptor to the c-fos promoter (S.J. Hill, A.C. Megson, E.M. Walker).Molecular basis for the cardiovascular adverse effects of first- andsecond-generation antihistamines (M. Taglialatela et al.). The skinreactivity to histamine: The traps of the investigation (J.-P. Rihoux, A.Campbell). Safety and efficiency of histamine H1 antagonists. Efficacy andsafety of H1-receptor antagonists in the treatment of allergic disorders: anoverview (F. Estelle, R. Simons). Histaminergic neurons and sleep-wakeregulation (J.S. Lin, G. Vanni-Mersier, R. Parmentier). Brain penetration ofebastine evaluated in human by positron emission tomography PET (M. Tagawa etal.). Signal transduction. Pathways of histamine H1receptor-induced Ca2+entry in an human astrocytoma cells (M.M.-P. Wong, J.M. Young). Qualitativestructure activity relationship for inverse agonism of histamine H2 receptor(A.E. Alewijnse et al.). Constitutive signalling of the human histamine H1receptor (R.A. Bakker et al.). H1-Histamine receptor communicates to G14 witha relatively higher affinity than to G11 (N. Nakahata et al.). Pathologicalsignificance of over-production of histamine and altered transcriptionalregulation of H1- and H2- receptors during septic shock (N.Matsuda et al.).Histamine receptors in the chick cerebral cortex: effects on cyclic AMPformation and characterization by radioreceptor binding (J.B. Zawilska, A.Wolan-Tambor, J.Zwak). Histaminergic effect on apoptosis of small intestinalmucosa after ischemia-reperfusion in the rat (K. Fujimoto et al.).Hypothalamus and histamine neurons. Changes in circadian rhythmicity andmelatonin balance in rats with portacaval anastomosis (PCA)-relation withhistamine (L. Tuomisto et al.). Histamine is a transmitter to maintain tonicfiring of mesopontine tegmental cholinergic neurons during wakefulness (Y.Koyama, K. Tkahashi, Y. Kayama). Effects of leptin on feeding in histamineH1-receptor knockout mice (T. Masaki et al.). Chronic histamine treatmentimproves impaired energy intake and hyperinsulinia in diet-induced obese mice(H. Yoshimatsu et al.). Neurotransmitter inputs to the tuberomammillaryneurons (K.S. Eriksson et al.). The difference of leptin-histamine signalingin the hypothalamus of obese animal models (H. Yoshimatsu et al.). A possibleinvolvement of the chorda tympani in the enhancement of the hypothalamichistamine release by leptin (T. Morimoto-Ishizuka et al.). H2 receptors anddiseases. Functional and morphological abnormality of gastric mucosa inhistamine H2 receptor (H2R)- deficientm mice (T. Watanabe et al.). Newperspectives for histamine-mediated CNS functions. A third legacy forburimamide: Discovery and characterization of improgan and a new class ofnon-opioid analgesics derived from histamine antagonist (L.B. Hough et al.).Involvement of central histamine in amygdaloid kindled seizures in rats (C.Kamei). The role of histamine in a hypocretin orexin-deficient sleepdisorder, narcolepsy (S. Nishino at al.). Central histamine and behavioralrespiration (I. Homma et al.). Peripheral neuronal histamine down regulatessympathetic activity and arterial pressure (H. Campos). Changes in brainhistamine H1 reseptors in chronic hepatic encephalopathy (V. Lozeva et al.).Activation of central histminergic system induced by histamine H3-receptorantagonists on anxiety and learning in mice (K. Onodera et al.). Mast cells,ECL cells and others. Role of Histamine and mast cells in metabolicencephalopathy (P.J. Langlais). Mast cell degranulation in the rat smallintestine: role of endothelin-A receptors (M. Boros, L. Szalay, J. Kaszaki)Altered response of (isolated) placental vessels to histamine in diabetescomplicated pregnancy (D. Szukiewicz et al.). Gastric submucosalmicrodialysis: A method to monitor ECL-cell histamine mobilization from ratstomach (M. Kitano et al.). The interaction between histamine H3receptors anddopamine D1 receptors in the regulation of [3H]-a-aminobutyric acid relaesein rat striatum (J.-A. Arias-Montano et al.). Immunohistochemicallocalization of histamine N-methyltransferase in the bovine central nervoussystem (M. Nishibori et al.). Histidine decarboxylase. Histidinedecarboxylase activity in hematopoietic progenitors as a marker for basophilpotentiality. Evidence for the existance of a common progenitor formegakaryocytes and basophils (M. Dy et al.). Endogenous histamine andallergic eosinophol infiltration into the airways (A. Korai et al.). Role ofhistamine in gastric acid secrection: L-hisidine decarboxylase deficient mice(S. Tanaka et al.). Histamine and allergic disease. Histamine as amediator of allergic airway disease (S. Holgate). Histamine and skin allergicdiseases (T. Koga, F. Kohda, M. Furue). Effects of a selective H1-receptorantagonist, epinastine, on airway inflammation in asthmatics (K. Kimura etal.). Mast cells and inflammation. Suppression of MAP kinase pathways inmast cells by glucocorticolds; mechanisms and consequences (M.A. Beaven, D.S.Cissel, T.R. Hundley). Antiasthmatic Indonesian Medicinal plants: Theirtracheospasmolytic activity against histamine induced contractions (S.Wahyuono et al.). Mast cells in rhinitis (R. Pawankar et al.). PosterSessions. Molecular biology and application. Characterization of splicingvariants of histamine H3 receptor (K. Tanaka et al.). Molecular cloning andcharacterization of a new subtype histamine receptor, H4 (T. Nakamura etal.). Genomic structure of histamine N-methyl-transferase in mammals (M.Takemura et al.). In situ hybridization analysis of gene expression ofhistamine H1 receptor in murine dorsal root and trigeminal ganglia (M. Itohet al.). L-Histamine decarboxylase protein and activity in rat brainmicrovascular endothelial cells (E. Sakurai et al.). Allergy, inflammationand immunology. Participation of histamine H1 and H2 receptors in theinduction of scratching behavior of ICR mice caused by IgE-mediated passivecutaneous anaphylaxis (N. Inagaki et al.). Immediate-type allergic reactionand helper T cell fuction in histamine H1 receptor- and H2 receptor-deficientmice (T. Kobayashi et al.). IL-18 production induced by histamine in humanPBMCs through H2 receptor stimulation (H. Kohka et al.). Regulatory mechanismof eosinophil peroxidase release from guinea pig eosinophils (Y. Kirino, M.Mio, C. Kamei). Induction of VEGF expression by histamine in the granulationtissue in rats (A.K. Ghosh, N. Hirasawa, K. Ohuchi). Induction of histidinedecarboxylase in the neointimal smooth muscle cells of balloon-injuredporcine coronary arteries (Y.-Il. Fang et al.). Localization of histamineN-methyltransferase in guinea pig tissues: an immunohistochemical study (A.Tahara et al.). Signal transduction. Agonist-mediated regulation ofhistamine H1 receptors and Ca2+ signaling: Ca2+/calmodulin-mediatedregulation of receptor function and distribution (S. Hishinuma). Involvementof protein kinase C in regulation of histamine H1 receptor expression in U373astrocytoma cells (R. Ishikawa et al.). Glucose overload attenuates histamineH2 receptor-mediated Ca2+ mobilization due to protein kinase C production inbovine cerebral endothelial cells (M. Oike, C. Kimura, Y. Ito). Studies ofhistamine H1 receptor down-regulation using mutant receptors lacking putativephosphorylation sites (M. Ogawa et al.). Mechanism underlyinghistamine-induced desensitization of amylase secretion in rat parotid glands(H. Ishida et al.). Regulation of histidine decarboxylase protein expressionin macrophages: Involvement of MAP kinases and inhibition by dexamethasone(A. Murakami et al.). Mast cells. Functional maturation of mouse culturedmast cells to a connective tissue mast cell-like phenotype in vitro (Y.Taketomi et et.). Functional differences between the connective tissue andmucosal mast cells on the contraction of isolated rat trachea (Z. Ikawati etal.). Rho GTPases regulate degranulation and cytokine release from RBL-2H3cells (I. Hide et al.). Effect of lipid peroxide on histamine release fromrat peritoneal mast cells (M. Akagi et al.). Effects of ultraviolet light UVon histamine release from rat peritoneal mast cells (M. Mio et al.).Placental mast cells and histamine in pregnancy complicated by intrauterinegrowth retardation (IUGR): relation to the development of villousmicrovessels (D. Szukiewicz et al.). Involvement of mast cells ininflammation sites of colitis induced by dextran sulfate sodium (Y. Iba, Y.Sugimoto, C. Kamei). Development of histamine sensor using recombinanthistamine oxidase (S. Iwaki et al.). H3 receptors and ligands. HistamineH3 receptor mRNA expression in adult rat brain: cloning of receptor isoformswith differential expression patterns (K.Karlstedt et al.). Histamine H3receptor-mediated regulation of glutamatergic synaptic transmission in thehippocampus and striatum (R.E. Brown et al.). Peripherally administeredciproxifan elevates hypothalamic histamine levels and potently reduces foodintake in the Sprague Dawley rat (C. Bjenning et al.). Peripherallyadministered histamine H3 antagonist potently reduces snacking behavior inthe obes Zucker rat (C. Bjenning, W. Liu, K. Rimvall). Auditory evokedpotentials in rats: Effects of anticonvulsants and thioperamide (S. Lensu etal.). Histamine H3-receptor activation modulates glutamate release from ratstriatal synaptosomes (A. Molina-Hernandez, A. Nunez, J.-A. Aria-Montano).CNS-1. Mechanism for the inhibition of amygdaloid kindled seizures inducedby histamine in rats (C. Okuma, T. Hirai, C. Kamei). The role of endogenoushistamine in learning and memory in rats (C. Kamei, Y. Sugimoto, Z. Chen)Effects of immunosuppressive drugs on food and kaolin intakes, andhypothalamic histamine turnover in rats (R. Oishi et al.). Glucagon-likepeptide 1 modulates histaminergic action in the central regulation of foodintake in rats (Y. Kuros et al.). Histamine-induced itch-scratch response andcutaneous nerve firing in mice: comparison with serotonin (H. Nojima, T.Maekawa, Y. Kuraishi). Intrathecal histamine elicites a scratching, bitingand licking behavior in mice (T. Orita et al.). The role of brain histaminein visceral pain and emotion: Analysis through functional neuroimaging inhuman barins (M. Kano et al.). CNS-2. Involvement of histamine receptorsin p-hydroxyamphetamine-induced head-twitch behavior (T. Tadano et al.). Therole of histaminergic neuron system in the methamphetamine induced behavioralsensitization: A study using histamine related gene knockout mice (Y. Kubotaet al.). Brain histamine as protective system for the formation of neuralsensitization (C. Ito, M. Sato, T. Watanabe). The changes of histamineconcentrations in the plasma and brain in response to acute stress (Z.-B.Yang et al.). Anti-stress effects of chicken essence in food-deprivedactivity stress: Possible involvement of histaminergic neurons (Z.-B. Yang etal.). Decreased histamine H1 receptors in the rat brain subjected tofood-deprived activity stress (M. Endou et al.). Central histamine influencesrespiration in the POA/AH (M. Iwase et al.). Central histamine is acontributory factor in temperature-induced polypnea in conscious mice (M.Izumizaki et al.). Histamine release in the medulla oblongata influencestracheal tone and blood pressure (M. Kanamaru, M. Iwase, I. Homma). Theeffects of histamine receptor antagonists on the induction of metallothioneinmRNA after lipopolysaccharide injection in the mouse spleen (N. Sogawa etal.). CNS-3. Evidence for the presence of histamine reuptake system in thebrain and its characterization (E. Sakurai et al.). The effects of"sleepiness" on the brain activity during spatial cognition tasks: A humanPET study (H. Mochizuki et al.). Index of authors