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Biotechnology 2nd, Completely Revised ed.(Biotechnology: A Multi–Volume Comprehensive Treatise Vol. 5A) H 580 p. 98

Mountain, A., Ney, U. M., Schomburg, Dietmar 　著

Rehm, Hans–Jürgen, Reed, Gerald, Pühler, Alfred, Stadler, Peter 　編

絶版
価格 \-

発行年月	1998年12月
出版社／提供元	Wiley-VCH Verlag GmbH
出版国	ドイツ
言語	英語
媒体	冊子
装丁	hardcover
ページ数／巻数	580 p.
ジャンル	洋書／理工学／化学工学／反応工学
ISBN	9783527283156
商品コード	0203070288
本の性格	学術書
商品URL	https://kw.maruzen.co.jp/ims/itemDetail.html?itmCd=0203070288

内容

Biotechnology Second, Completely Revised Edition Edited by H.–J. Rehm and G. Reed in cooperation with A. Pühler and P. Stadler This fully revised and expanded Second Edition takes into account all recent developments in biotechnology. It is extraordinarily broad in scope, up–to–date, carefully structured and well–balanced. "Biotechnology" considers both basic concepts and widely–differing industrial applications: it is a successful synthesis of theory and practice. Any scientist aiming for success in industrial microbiology, biochemistry, molecular biology and chemical engineering must turn to "Biotechnology". Volume 5a: Proteins are the molecules of choice when highly specific medical treatments or other highly specific technical properties are requried. The first chapters provide an overview of protein structure and function and of the design and uses of recombinant proteins. Options and issues of antibody therapies are discussed in chapters ranging from the design and manufacture of antibodies through pre–clinical testing and clinical development. The new approach to treatment of disease by targeted gene therapy is reviewed demonstrating the extent of challenges still to be met before gene therapy products can be used successfully. The rapidly changing global regulatory environment and pharmacoeconomic issues for products of biotechnology are also highlighted. Topics included are: Structure and Function of Proteins ?? Recombinant Proteins: In vitro Folding ?? Medical Applications ?? Industrial Applications ?? Monoclonal Antibodies: Engineering and Expression ?? Manufacture ?? Preclinical Testing ?? Therapeutic Applications ?? Case Studies ?? Gene Therapy: Vectors ?? Large–Scale Plasmid DNA Manufacturing ?? Regulatory and Economic Aspects

STRUCTURE AND FUNCTION OF PROTEINS. Types and Function of Proteins (S. Wolf & H. Gassen). Sequence and Structure of Proteins (F. Eisenhaber & P. Bork). Protein Interactions (M. Meyer & D. Schomburg). RECOMBINANT PROTEINS. In vitro Folding of Inclusion Body Proteins on an Industrial Scale (R. Rudolph, et al.). Medical Applications of Recombinant Proteins in Humans and Animals (G. Wetzel). Enzymes for Industrial Applications (W. Aehle & O. Misset). MONOCLONAL ANTIBODIES. Antibody Engineering and Expression (J. Adair). Manufacture of Therapeutic Antibodies (A.J. Racher, et al.). Use of Antibodies for Immuno–purification (D. King). Preclinical Testing of Antibodies: Pharmacology, Kinetics, and Immunogenicity (R. Foulkes & S. Stephens). Preclinical Testing of Antibodies: Safety Aspects (R. James). Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (M. Sopwith). CASE STUDIES. Antibodies for Sepsis: Some Lessons Learnt (S. Opal). An Engineered Human Antibody for Chronic Therapy: CDP571 (M. Sopwith & S. Stephens). Antibody Targeted Chemotherapy (M. Berger, et al.). ReoPro Clinical Development: A Case Study (H. Weisman). GENE THERAPY. Overview of Gene Therapy (A. Mountain). Viral Vectors for Gene Therapy (B. Carter). Non–Viral Vectors for Gene Therapy (N. Weir). Issues for Large–Scale Plasmid DNA Manufacturing (M. Schleef). Gene Therapy for HIV Infection (M. Poznansky, et al.). REGULATORY AND ECONOMIC ASPECTS. Regulation of Antibodies and Recombinant Proteins (J. Foulkes & G. Traynor). Regulation of Human Gene Therapy (J. Parker). Economic Considerations (I. Nicholson). Index.