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CLASSICAL TECHNIQUESUsing Spectroscopic Techniques to Examine Drug-DNA InteractionsSpectroscopic Methods of AnalysisProbing DNA and RNA Interactions with Biogenic and Synthetic Polyamines: Models and Biological ImplicationsAnalytical methods used for structural analysis of polyamine-nucleic acid complexesEMERGING TECHNIQUESMass Spectrometry-Based Techniques for Studying Nucleic Acid/Small Molecule InteractionsBasics of ESI-MS Screening and DetectionReal-Time Monitoring of Nucleic Acid Interactions with Biosensor-Surface Plasmon Resonance Basic components and steps in a biosensor-SPR experimentStudying Aptamer/Ligand Interactions Using Fluorescence Correlation SpectroscopyBasics of fluorescence correlation spectroscopyStudying Nucleic Acid - Drug Interactions at the Single Molecule Level Using Optical TweezersFluorescent Nucleoside Analogues for Monitoring RNA–Drug InteractionsBasics of Fluorescence SpectroscopyAtomic Force Microscopy Investigation of DNA-Drug InteractionsBasics of AFM for biomedical researchCharacterizing RNA-Ligand Interactions Using 2-Dimensional Combinatorial ScreeningEPR Spectroscopy for the Study of RNA-Ligand InteractionsCase studies: Structural dynamics of the TAR RNAElectrochemical Approaches to the Study of DNA-Drug InteractionsNanopore Ion Microscope for Detecting Nucleic Acid/Drug InteractionsBasics of Nanopore SensingA Primer for Relaxation Kinetic MeasurementsCase Studies: Binding to Nucleic Acids and Statistically Excluded Site BindingDNA-Drug Interactions: A Theoretical PerspectiveComputational Studies of RNA Dynamics and RNA-Ligand InteractionsSimulating RNA and its complexes with small moleculesAll chapters include case studies, background and basics, prospects and outlook, conclusions, and references