Andrushko, V 　著

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Preface List of contributors List of symbols and abbreviations PART 1: GENERAL METHODS AND STRATEGIES Chapter 1: Principles, concepts and strategies of stereoselective synthesis Vasyl Andrushko and Natalia Andrushko Chapter 2: Chiral auxiliaries in drug synthesis Stanley Chang, Shira D. Halperin, Jarod Moore and Robert Britton Chapter 3: Solid–phase organic synthesis of drugs and natural products Peter J. H. Scott Chapter 4: Asymmetric phase–transfer catalysis Kohsuke Ohmatsu, Daisuke Uraguchi, and Takashi Ooi Chapter 5: Microwave–assisted stereoselective synthesis Yoann Coquerel, Evelina Colacino, Jean Rodriguez, Jean Martinez and Frédéric Lamaty Chapter 6: Application of micro reactor methodology for organic synthesis Paul Watts and Charlotte Wiles PART 2: STEREOSELECTIVE SYNTHESIS BY BOND FORMATION 2.1. STEREOSELECTIVE METHODS FOR C???C BOND FORMATION Chapter 7: Asymmetric ??–alkylation of aldehydes, ketones and carboxylic acids Mark C. Kohler, Sarah E. Wengryniuk, and Don M. Coltart Chapter 8: Asymmetric aldol reactions in the total syntheses of natural products Seijiro Hosokawa Chapter 9: Asymmetric Michael addition and related reactions Pengfei Li, Jun Wang and Fuk Yee Kwong Chapter 10: Construction of polypropionate fragments in natural product synthesis Maris Turks, Sylvain Laclef and Pierre Vogel Chapter 11: Organocatalytic conjugate addition in stereoselective synthesis Adrien Quintard and Alexandre Alexakis Chapter 12: Stereoselective Nozaki–Hiyama–Kishi reaction Pat Guiry and Gráinne Hargaden Chapter 13: Transition–metal–catalyzed asymmetric C???C cross–couplings in stereoselective synthesis Vasiliki Sarli Chapter 14: Asymmetric hydroformylation, hydroxy– and alkoxycarbonylation for stereoselective synthesis Jamie T. Durrani and Matthew L. Clarke Chapter 15: Intramolecular oxycarbonylation in stereoselective synthesis Tibor Gracza Chapter 16: Stereoselective cycloaddition reactions Tae–Kyung Lee and Jung–Mo Ahn Chapter 17: Sigmatropic rearrangements in stereoselective synthesis Brinton Seashore–Ludlow and Peter Somfai Chapter 18: Ring contraction reactions in the total synthesis of biologically active natural products Luiz F. Silva Jr. Chapter 19: Electrocyclic reactions in stereoselective synthesis Marcus A. Tius Chapter 20: Transannular cyclization in natural product total synthesis Jiong Yang and Haoran Xue Chapter 21: Cascade reactions in stereoselective synthesis Bor–Cherng Hong and Nitin S. Dange Chapter 22: Sulfur dioxide: a powerful tool for the stereoselective construction of C–C bonds Pierre Vogel, Dean Markovic and Mâris Turks Chapter 23: Transition metal C–H activation: application to stereoselective synthesis of natural products and drugs Mickaël Jean and Pierre van de Weghe Chapter 24: Metathesis reactions in drug and natural product synthesis Akio Saito, Yuji Hanzawa Chapter 25: Radicals in stereoselective C–C bond formation Josep Bonjoch, Ben Bradshaw and Faïza Diaba Chapter 26: Trifluoromethyl (CF3) group insertion methods in stereoselective synthesis Tsutomu Konno Chapter 27: Stereoselective organocatalyzed C???C bond–forming reactions Kazuo Nagasawa and Koji Yasui Chapter 28: Enzyme–catalysed stereoselective C???C bond formation reactions in total syntheses Adeline Ranoux and Ulf Hanefeld 2.2. STEREOSELECTIVE METHODS FOR C???H BOND FORMATION Chapter 29: Stereoselective hydrogenation of C=C bonds: application to drug and natural product synthesis Natalia Andrushko and Vasyl Andrushko Chapter 30: Asymmetric hydrogenation of C=O and C=N bonds in stereoselective synthesis Natalia Andrushko and Vasyl Andrushko Chapter 31: Asymmetric protonation of carbanions and polar double bonds: application to total syntheses Thomas Poisson and Shu Kobayashi Chapter 32: Organocatalytic reduction in stereoselective synthesis Felix Kortmann and Adriaan Minnaard Chapter 33: Biocatalytic asymmetric reduction of C=O and activated C=C bonds in stereoselective synthesis Tomoko Matsuda, Rio Yamanaka and Kaoru Nakamura 2.3. STEREOSELECTIVE METHODS FOR C???O BOND FORMATION Chapter 34: Transition–metal–catalyzed stereoselective oxidations in drug and natural product synthesis Alessandro Scarso and Giorgio Strukul Chapter 35: Asymmetric epoxidation in stereoselective synthesis Zhicai Yang Chapter 36: Biocatalytic asymmetric oxidations in stereoselective synthesis Anett Schallmey, Pablo Dominguez de Maria and Paula Bracco Chapter 37: Ether transfer methodology: application to the synthesis of polyketide natural products Eric Stefan and Richard E. Taylor Chapter 38: Stereoselective formation of 2–deoxyglycosidic bonds in biologically active natural products Daisuke Takahashi and Kazunobu Toshima 2.4. STEREOSELECTIVE METHODS FOR C???N BOND FORMATION Chapter 39: Asymmetric hydroamination and reductive amination in total synthesis Manas K. Ghorai, Deo Prakash Tiwari and Aditya Bhattacharyya Chapter 40: Carboamination and alkylative cyclization with C–N bond formation in stereoselective syntheses Manas K. Ghorai, Sandipan Halder and Sauvik Samanta Chapter 41: Cycloadditions with stereoselective C–N bond formation in total syntheses Guillaume Vincent 2.5. STEREOSELECTIVE FORMATION OF OTHER C???HETEROATOM AND OTHER BONDS Chapter 42: Stereoselective halogenations Chong Kiat Tan, Yi Zhao, Jing Zhou and Ying–Yeung Yeung Chapter 43: Stereoselective synthesis of halogenated natural products Takehiko Yoshimitsu Chapter 44: Asymmetric fluorination methods: application in the stereoselective synthesis of fluorinated drugs Vincent Bizet and Dominique Cahard Chapter 45: Enzymatic halogenation in stereoselective synthesis Cormac D. Murphy and Benjamin R. Clark Chapter 46: Stereoselective carbon???sulfur (C???S) bond formation Kyungsoo Oh Chapter 47: Stereoselective methods for carbon–phosphorus (C???P) bond formation Marcin Kalek and Jacek Stawinski Chapter 48: Transition–metal–catalyzed asymmetric sulfoxidation in drug and natural product synthesis Alessandro Scarso and Giorgio Strukul PART 3: METHODS OF ANALYSIS AND CHIRAL SEPARATION Chapter 49: NMR–Spectroscopy in drug and natural product analysis Stanisuaw Witkowski and Iwona Wawer Chapter 50: Determination of enantiomeric purity and absolute configuration by NMR spectroscopy Thomas J. Wenzel Chapter 51: Solid–state NMR spectroscopy in drug design and discovery David A. Middleton and Simon G. Patching Chapter 52: Capillary electrophoresis in chiral separations Ans Hendrickx, Debby Mangelings and Yvan Vander Heyden Chapter 53: Determination of absolute configuration using chiroptical methods Joao Marcos Batista, Jr. Chapter 54: Chiral chromatographic methods in the analysis and purification of enantiomers Arnau Novell and Cristina Minguillón Chapter 55: X–Ray crystallography and 1H NMR anisotropy methods for determination of absolute configurations Nobuyuki Harada Chapter 56: Crystallization based separation of enantiomers Yaling Wang and Alex Chen Chapter 57: Enzymatic dynamic kinetic resolution in stereoselective synthesis Francisca Rebolledo, Javier González–Sabín, and Vicente Gotor Subject index