内容

目次

1. A Brief History of Epigenetics 2. Outlook: Looking into Epigenetics i) The Discovery of Histone Demethylases ii) Cellular Reprogramming iii) IncRNAs: Linking RNA to Chromatin iv) Enhancer RNAs: A Class of Long Noncoding RNAs Synthesized at Enhancers v) Novel Modifications of Cytosine in Genomic DNA vi) Plant Mobile Small RNAs vii) CpG island Chromatin is Shaped by Recruitment of ZF-CxxC Proteins viii) A Bromodomain and Extraterminal Domain Inhibitor (BETi) for Cancer Therapy ix) BET Inhibitors II x) Histone H3 Mutations in Pediatric Brain Tumors xi) Chromosome Folding: Driver or Passenger of Epigenetic State 3. Overview and Concepts 4. Writers and Readers of Histone Acetylation: Structure, Mechanism and Inhibition 5. Erasers of Histone Acetylation: The Histone Deacetylase Enzymes 6. Structural and Functional Coordination of DNA and Histone Methylation 7. A Structural Perspective on Readout of Epigenetic H & DM Marks 8. Epigenetics in Saccharomyces cerevisiae 9. Epigenetics in Saccharomyces pombe 10. Neurospora crassa, a Model System for Epigenetics Research 11. Epigenetics of Ciliates 12. Position Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila 13. Epigenetic Regulation in Plants 14. The Use of Mouse Models to Study Epigenetics 15. DNA Methylation in Mammals 16. RNAi and Primal RNAs 17. Transcriptional Silencing by Polycomb Group Proteins 18. Transcriptional Regulation by Trithorax Group Proteins 19. Long-range Chromatin Interactions 20. Histone Variants and Epigenetic Inheritance 21. Nucleosome Remodeling and Epigenetics 22. Maintenance of Epigenetic Information 23. Regulation of the X Chromosomes in C. elegans 24. Dosage Compensation in Drosophila 25. Dosage Compensation in Mammals 26. Genomic Imprinting in Mammals 27. Germ Line and Pluripotent Stem Cells 28. Induced Pluripotency and Epigenetic Reprogramming 29. Epigenetic Control of Immunity 30. Metabolic Signalling to Chromatin 31. Epigenetic Regulation in Plant Responses to the Environment 32. Epigenetic Regulation in Neuronal Development 33. Epigenetics and Human Disease 34. Epigenetic Determinants of Cancer 35. Epigenetics and Cancer II 36. Perspectives on Epigenetics